Parafibromin--functional insights.
Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly cons...
| Egile Nagusiak: | , , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2009
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| _version_ | 1826257865221865472 |
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| author | Newey, P Bowl, MR Thakker, R |
| author_facet | Newey, P Bowl, MR Thakker, R |
| author_sort | Newey, P |
| collection | OXFORD |
| description | Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults. |
| first_indexed | 2024-03-06T18:24:56Z |
| format | Journal article |
| id | oxford-uuid:079e7e1d-0aef-452c-a87c-a83f4ffcf413 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:24:56Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:079e7e1d-0aef-452c-a87c-a83f4ffcf4132022-03-26T09:08:33ZParafibromin--functional insights.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:079e7e1d-0aef-452c-a87c-a83f4ffcf413EnglishSymplectic Elements at Oxford2009Newey, PBowl, MRThakker, RParafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults. |
| spellingShingle | Newey, P Bowl, MR Thakker, R Parafibromin--functional insights. |
| title | Parafibromin--functional insights. |
| title_full | Parafibromin--functional insights. |
| title_fullStr | Parafibromin--functional insights. |
| title_full_unstemmed | Parafibromin--functional insights. |
| title_short | Parafibromin--functional insights. |
| title_sort | parafibromin functional insights |
| work_keys_str_mv | AT neweyp parafibrominfunctionalinsights AT bowlmr parafibrominfunctionalinsights AT thakkerr parafibrominfunctionalinsights |