Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.

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MLL1 fusion proteins activate HoxA9 gene expression and cause aggressive leukemias that respond poorly to treatment, but how they recognize and stably bind to HoxA9 is not clearly understood. In a systematic analysis of MLL1 domain recruitment activity, we identified an essential MLL1 recruitment do...

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Библиографические подробности
Главные авторы:	Milne, T, Kim, J, Wang, G, Stadler, S, Basrur, V, Whitcomb, S, Wang, Z, Ruthenburg, A, Elenitoba-Johnson, K, Roeder, R, Allis, C
Формат:	Journal article
Язык:	English
Опубликовано:	2010

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