A metathesis-based approach to the synthesis of 2-pyridones and pyridines.
The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compound...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826257885272735744 |
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| author | Donohoe, T Fishlock, L Procopiou, P |
| author_facet | Donohoe, T Fishlock, L Procopiou, P |
| author_sort | Donohoe, T |
| collection | OXFORD |
| description | The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compounds then provides access to a wide variety of substituted pyridines in excellent overall yield. |
| first_indexed | 2024-03-06T18:25:15Z |
| format | Journal article |
| id | oxford-uuid:07b9c166-ab0b-424d-b53d-4da45e446773 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:25:15Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:07b9c166-ab0b-424d-b53d-4da45e4467732022-03-26T09:09:08ZA metathesis-based approach to the synthesis of 2-pyridones and pyridines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:07b9c166-ab0b-424d-b53d-4da45e446773EnglishSymplectic Elements at Oxford2008Donohoe, TFishlock, LProcopiou, PThe ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compounds then provides access to a wide variety of substituted pyridines in excellent overall yield. |
| spellingShingle | Donohoe, T Fishlock, L Procopiou, P A metathesis-based approach to the synthesis of 2-pyridones and pyridines. |
| title | A metathesis-based approach to the synthesis of 2-pyridones and pyridines. |
| title_full | A metathesis-based approach to the synthesis of 2-pyridones and pyridines. |
| title_fullStr | A metathesis-based approach to the synthesis of 2-pyridones and pyridines. |
| title_full_unstemmed | A metathesis-based approach to the synthesis of 2-pyridones and pyridines. |
| title_short | A metathesis-based approach to the synthesis of 2-pyridones and pyridines. |
| title_sort | metathesis based approach to the synthesis of 2 pyridones and pyridines |
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