Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

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RATIONALE:: Creatine is thought to be involved in the spatial and temporal buffering of ATP in energetic organs such as heart and skeletal muscle. Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardial creatine are a hallmark of the failing heart,...

Bibliografski detalji
Glavni autori:	Lygate, C, Aksentijevic, D, Dawson, D, Ten Hove, M, Phillips, D, De Bono, J, Medway, D, Sebag-Montefiore, L, Hunyor, I, Channon, K, Clarke, K, Zervou, S, Watkins, H, Balaban, R, Neubauer, S
Format:	Journal article
Jezik:	English
Izdano:	2013

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Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
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Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
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Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
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Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine
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Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart
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Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.
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Mechanisms of creatine depletion in chronically failing rat heart.
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Hearts from gamt ko mice lack phospho-creatine, show reduced inotropic reserve and are more prone to ischemia
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Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
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