Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

RATIONALE:: Creatine is thought to be involved in the spatial and temporal buffering of ATP in energetic organs such as heart and skeletal muscle. Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardial creatine are a hallmark of the failing heart,...

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Detalhes bibliográficos
Principais autores: Lygate, C, Aksentijevic, D, Dawson, D, Ten Hove, M, Phillips, D, De Bono, J, Medway, D, Sebag-Montefiore, L, Hunyor, I, Channon, K, Clarke, K, Zervou, S, Watkins, H, Balaban, R, Neubauer, S
Formato: Journal article
Idioma:English
Publicado em: 2013