Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community.
BACKGROUND: Alzheimer's disease (AD) is suspected to be currently under-diagnosed in India, thus the need for a brief, effective screening test for the condition. AIMS: We aimed to test the Malayalam translation of the 7-Minute Screen (7MS) for detecting those at high risk for AD and to report...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797051869274570752 |
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| author | de Jager, C Thambisetty, M Praveen, K Sheeba, P Ajini, K Sajeev, A Smitha, K Rahmathulla, L Ramakrishna, T David, SA |
| author_facet | de Jager, C Thambisetty, M Praveen, K Sheeba, P Ajini, K Sajeev, A Smitha, K Rahmathulla, L Ramakrishna, T David, SA |
| author_sort | de Jager, C |
| collection | OXFORD |
| description | BACKGROUND: Alzheimer's disease (AD) is suspected to be currently under-diagnosed in India, thus the need for a brief, effective screening test for the condition. AIMS: We aimed to test the Malayalam translation of the 7-Minute Screen (7MS) for detecting those at high risk for AD and to report on the subscores used to derive the Alzheimer's risk score. SETTING AND DESIGN: This study was performed in Kerala State amongst young university students and elders in residential care homes. MATERIALS AND METHODS: Two hundred and eighty-two volunteers were tested, 178 young controls (aged 20-29) and 104 literate elders, (55-92 years). None were clinically diagnosed with AD. STATISTICAL ANALYSES: Elders and controls were assessed as High or Low AD Risk with the published 7MS algorithm. Performance was compared between groups with ANOVA. RESULTS: The algorithm estimated high (n=61/104) or low (n=40/104) AD risk in the elderly. Significant differences were found between controls, low- and high-risk groups on all four components of the screen (Orientation: F=131.1, Enhanced Cued Recall: F=23.4, Clock Drawing: F=65.1, Verbal Fluency: F=15.7, P<0.0001 for all) and in the risk scores (F=144.7, P<0.0001). Age and gender affected verbal fluency, orientation and clock drawing performance. The high-risk group had worse scores for orientation and better scores for memory than previously reported for AD cases in other populations. CONCLUSIONS: The 7MS may be a useful screening test for cognitive impairment in India. Suggestions are given for revising the 'risk algorithm' for more appropriate AD risk assessment in this population. |
| first_indexed | 2024-03-06T18:25:32Z |
| format | Journal article |
| id | oxford-uuid:07d1502d-819a-47e6-9b82-34e074d503f0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:25:32Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:07d1502d-819a-47e6-9b82-34e074d503f02022-03-26T09:09:37ZUtility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:07d1502d-819a-47e6-9b82-34e074d503f0EnglishSymplectic Elements at Oxford2008de Jager, CThambisetty, MPraveen, KSheeba, PAjini, KSajeev, ASmitha, KRahmathulla, LRamakrishna, TDavid, SA BACKGROUND: Alzheimer's disease (AD) is suspected to be currently under-diagnosed in India, thus the need for a brief, effective screening test for the condition. AIMS: We aimed to test the Malayalam translation of the 7-Minute Screen (7MS) for detecting those at high risk for AD and to report on the subscores used to derive the Alzheimer's risk score. SETTING AND DESIGN: This study was performed in Kerala State amongst young university students and elders in residential care homes. MATERIALS AND METHODS: Two hundred and eighty-two volunteers were tested, 178 young controls (aged 20-29) and 104 literate elders, (55-92 years). None were clinically diagnosed with AD. STATISTICAL ANALYSES: Elders and controls were assessed as High or Low AD Risk with the published 7MS algorithm. Performance was compared between groups with ANOVA. RESULTS: The algorithm estimated high (n=61/104) or low (n=40/104) AD risk in the elderly. Significant differences were found between controls, low- and high-risk groups on all four components of the screen (Orientation: F=131.1, Enhanced Cued Recall: F=23.4, Clock Drawing: F=65.1, Verbal Fluency: F=15.7, P<0.0001 for all) and in the risk scores (F=144.7, P<0.0001). Age and gender affected verbal fluency, orientation and clock drawing performance. The high-risk group had worse scores for orientation and better scores for memory than previously reported for AD cases in other populations. CONCLUSIONS: The 7MS may be a useful screening test for cognitive impairment in India. Suggestions are given for revising the 'risk algorithm' for more appropriate AD risk assessment in this population. |
| spellingShingle | de Jager, C Thambisetty, M Praveen, K Sheeba, P Ajini, K Sajeev, A Smitha, K Rahmathulla, L Ramakrishna, T David, SA Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community. |
| title | Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community. |
| title_full | Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community. |
| title_fullStr | Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community. |
| title_full_unstemmed | Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community. |
| title_short | Utility of the Malayalam translation of the 7- minute screen for Alzheimer's disease risk in an Indian community. |
| title_sort | utility of the malayalam translation of the 7 minute screen for alzheimer s disease risk in an indian community |
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