Antioxidants and preterm prelabour rupture of the membranes.
OBJECTIVE: To investigate the relationships of dietary intakes and serum levels of antioxidant nutrients to the risk of prelabour rupture of the membranes preterm (PPROM). DESIGN: A prospective observational cohort study. SETTING: A district general hospital in the south of England. POPULATION: Eig...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797051937999290368 |
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| author | Mathews, F Neil, H |
| author_facet | Mathews, F Neil, H |
| author_sort | Mathews, F |
| collection | OXFORD |
| description | OBJECTIVE: To investigate the relationships of dietary intakes and serum levels of antioxidant nutrients to the risk of prelabour rupture of the membranes preterm (PPROM). DESIGN: A prospective observational cohort study. SETTING: A district general hospital in the south of England. POPULATION: Eight hundred and twelve white nulliparous women with singleton pregnancies. METHODS: Serum antioxidant concentrations and dietary intakes were measured in the second trimester. Associations with the risk of PPROM were investigated. MAIN OUTCOME MEASURE: Preterm prelabour rupture of the membranes. RESULT: Serum concentrations of the antioxidant lutein, but no other nutrient, was associated with the risk of PPROM. Maternal smoke exposure (serum cotinine) also predicted PPROM. Women with high serum lutein concentrations (top third) in early pregnancy had four times greater risk than women in the lowest third (95% CI 1.3-11.9; P= 0.009) after adjusting for smoke exposure. Similar results were obtained using lutein levels from later pregnancy. CONCLUSION: We found no evidence that antioxidant nutrients are protective against PPROM. Rather, high levels of lutein were associated with an increased risk. |
| first_indexed | 2024-03-06T18:26:13Z |
| format | Journal article |
| id | oxford-uuid:080ddd10-b636-4d39-9b23-56987153754b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:26:13Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:080ddd10-b636-4d39-9b23-56987153754b2022-03-26T09:10:49ZAntioxidants and preterm prelabour rupture of the membranes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:080ddd10-b636-4d39-9b23-56987153754bEnglishSymplectic Elements at Oxford2005Mathews, FNeil, H OBJECTIVE: To investigate the relationships of dietary intakes and serum levels of antioxidant nutrients to the risk of prelabour rupture of the membranes preterm (PPROM). DESIGN: A prospective observational cohort study. SETTING: A district general hospital in the south of England. POPULATION: Eight hundred and twelve white nulliparous women with singleton pregnancies. METHODS: Serum antioxidant concentrations and dietary intakes were measured in the second trimester. Associations with the risk of PPROM were investigated. MAIN OUTCOME MEASURE: Preterm prelabour rupture of the membranes. RESULT: Serum concentrations of the antioxidant lutein, but no other nutrient, was associated with the risk of PPROM. Maternal smoke exposure (serum cotinine) also predicted PPROM. Women with high serum lutein concentrations (top third) in early pregnancy had four times greater risk than women in the lowest third (95% CI 1.3-11.9; P= 0.009) after adjusting for smoke exposure. Similar results were obtained using lutein levels from later pregnancy. CONCLUSION: We found no evidence that antioxidant nutrients are protective against PPROM. Rather, high levels of lutein were associated with an increased risk. |
| spellingShingle | Mathews, F Neil, H Antioxidants and preterm prelabour rupture of the membranes. |
| title | Antioxidants and preterm prelabour rupture of the membranes. |
| title_full | Antioxidants and preterm prelabour rupture of the membranes. |
| title_fullStr | Antioxidants and preterm prelabour rupture of the membranes. |
| title_full_unstemmed | Antioxidants and preterm prelabour rupture of the membranes. |
| title_short | Antioxidants and preterm prelabour rupture of the membranes. |
| title_sort | antioxidants and preterm prelabour rupture of the membranes |
| work_keys_str_mv | AT mathewsf antioxidantsandpretermprelabourruptureofthemembranes AT neilh antioxidantsandpretermprelabourruptureofthemembranes |