Intrinsic disorder in the T cell receptor creates cooperativity and controls ZAP70 binding
Many immunoreceptors have cytoplasmic domains that are intrinsically disordered (i.e., have high configurational entropy), have multiple sites of posttranslational modification (e.g., tyrosine phosphorylation), and participate in nonlinear signaling pathways (e.g., exhibiting switch-like behavior)....
| Auteurs principaux: | , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
Elsevier
2020
|