A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

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Bibliografski detalji
Glavni autori:	Higgins, G, Prevo, R, Lee, Y, Helleday, T, Muschel, R, Taylor, S, Yoshimura, M, Hickson, I, Bernhard, E, Mckenna, W
Format:	Journal article
Izdano:	2010

Slični predmeti

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.
od: Higgins, G, i dr.
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POLQ (DNA polyermase theta) as a novel therapeutic target: preclinical and clinical data
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Overexpression of POLQ confers a poor prognosis in early breast cancer patients.
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NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity.
od: Fokas, E, i dr.
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POLQ knockdown inhibits proliferation, migration, and invasion by inducing cell cycle arrest in colorectal cancer
od: Qing Yao, i dr.
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Knockdown of POLQ interferes the development and progression of hepatocellular carcinoma through regulating cell proliferation, apoptosis and migration
od: Qi Pan, i dr.
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NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
od: Fokas Emmanouil, i dr.
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Depletion of Signal Recognition Particle 72kDa increases radiosensitivity
od: Prevo, R, i dr.
Izdano: (2017)

Modifying radiosensitivity in tumors: Targeting the Ras-PI-3 kinase pathway.
od: Muschel, R, i dr.
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Knockdown of ATRX enhances radiosensitivity in glioblastoma
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Gelsolin knockdown confers radiosensitivity to glioblastoma cells
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A siRNA screen to identify molecular determinants of tumour radiosensitivity
od: Higgins, G, i dr.
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POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma
od: Laura del Puerto-Nevado, i dr.
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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
od: Belan, O, i dr.
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Dual loss of human POLQ and LIG4 abolishes random integration
od: Shinta Saito, i dr.
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Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells
od: Li H, i dr.
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Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells
od: Yanzhu Lin, i dr.
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HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.
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TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy
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POLQ identifies a better response subset to immunotherapy in muscle‐invasive bladder cancer with high PD‐L1
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Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
od: Kim, I, i dr.
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Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.
od: Prevo, R, i dr.
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
od: Ashton, T, i dr.
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Increasing radiosensitivity by alleviating tumour hypoxia: a drug screen reveals atovaquone as a clinical candidate
od: Ashton, T, i dr.
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Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature.
od: Fokas, E, i dr.
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The influence of Ras pathway signaling on tumor radiosensitivity.
od: Kim, I, i dr.
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Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922
od: Annett Kühnel, i dr.
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Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis
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CircROBO1 knockdown improves the radiosensitivity of hepatocellular carcinoma by regulating RAD21
od: Kai Yang, i dr.
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Molecular radiosensitization of pancreatic carcinoma cell lines in vivo and in vitro
od: Cengel, K, i dr.
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POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase
od: Yanmei Peng, i dr.
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The clinical implications of gemcitabine radiosensitization.
od: Doyle, T, i dr.
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SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells
od: Antje Güttler, i dr.
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Targeting ATR in DNA damage response and cancer therapeutics.
od: Fokas, E, i dr.
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The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells
od: Gonnissen, A, i dr.
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
od: Thomas M. Ashton, i dr.
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Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development
od: Summer B. Thyme, i dr.
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MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism
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od: Fokas, E, i dr.
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