A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

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Bibliográfalaš dieđut
Váldodahkkit:	Higgins, G, Prevo, R, Lee, Y, Helleday, T, Muschel, R, Taylor, S, Yoshimura, M, Hickson, I, Bernhard, E, Mckenna, W
Materiálatiipa:	Journal article
Almmustuhtton:	2010

Geahča maid

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NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
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POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma
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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
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Dual loss of human POLQ and LIG4 abolishes random integration
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POLQ identifies a better response subset to immunotherapy in muscle‐invasive bladder cancer with high PD‐L1
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Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature.
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The influence of Ras pathway signaling on tumor radiosensitivity.
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Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis
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CircROBO1 knockdown improves the radiosensitivity of hepatocellular carcinoma by regulating RAD21
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Molecular radiosensitization of pancreatic carcinoma cell lines in vivo and in vitro
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POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase
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The clinical implications of gemcitabine radiosensitization.
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SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells
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The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
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Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development
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MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism
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