Laser-based method and sample handling protocol for measuring breath acetone.
A robust method is demonstrated to measure acetone in human breath at sub parts-per-million by volume (ppmv) concentrations using diode laser cavity enhanced absorption spectroscopy. The laser operates in the near-infrared at about 1690 nm probing overtone transitions in acetone in a spectral region...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797052007370981376 |
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| author | Hancock, G Langley, C Peverall, R Ritchie, G Taylor, D |
| author_facet | Hancock, G Langley, C Peverall, R Ritchie, G Taylor, D |
| author_sort | Hancock, G |
| collection | OXFORD |
| description | A robust method is demonstrated to measure acetone in human breath at sub parts-per-million by volume (ppmv) concentrations using diode laser cavity enhanced absorption spectroscopy. The laser operates in the near-infrared at about 1690 nm probing overtone transitions in acetone in a spectral region relatively free from interference from common breath species such as CO2, water, and methane. Using an optical cavity with a length of 45 cm, bound by mirrors of 99.997% reflectivity, a limit of detection of ∼180 parts-per-billion by volume (ppbv) (1σ) of breath acetone is achieved. The method is validated with measurements made with an ion-molecule reaction mass spectrometer. A technique to calibrate the optical cavity mirror reflectivity using a temperature dependent water vapor source is also described. |
| first_indexed | 2024-03-06T18:26:57Z |
| format | Journal article |
| id | oxford-uuid:084bb74f-b755-49c9-b211-1bed4a3a4e3e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:26:57Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:084bb74f-b755-49c9-b211-1bed4a3a4e3e2022-03-26T09:12:09ZLaser-based method and sample handling protocol for measuring breath acetone.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:084bb74f-b755-49c9-b211-1bed4a3a4e3eEnglishSymplectic Elements at Oxford2014Hancock, GLangley, CPeverall, RRitchie, GTaylor, DA robust method is demonstrated to measure acetone in human breath at sub parts-per-million by volume (ppmv) concentrations using diode laser cavity enhanced absorption spectroscopy. The laser operates in the near-infrared at about 1690 nm probing overtone transitions in acetone in a spectral region relatively free from interference from common breath species such as CO2, water, and methane. Using an optical cavity with a length of 45 cm, bound by mirrors of 99.997% reflectivity, a limit of detection of ∼180 parts-per-billion by volume (ppbv) (1σ) of breath acetone is achieved. The method is validated with measurements made with an ion-molecule reaction mass spectrometer. A technique to calibrate the optical cavity mirror reflectivity using a temperature dependent water vapor source is also described. |
| spellingShingle | Hancock, G Langley, C Peverall, R Ritchie, G Taylor, D Laser-based method and sample handling protocol for measuring breath acetone. |
| title | Laser-based method and sample handling protocol for measuring breath acetone. |
| title_full | Laser-based method and sample handling protocol for measuring breath acetone. |
| title_fullStr | Laser-based method and sample handling protocol for measuring breath acetone. |
| title_full_unstemmed | Laser-based method and sample handling protocol for measuring breath acetone. |
| title_short | Laser-based method and sample handling protocol for measuring breath acetone. |
| title_sort | laser based method and sample handling protocol for measuring breath acetone |
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