Molecular basis and regulation of OTULIN-LUBAC interaction

Molecular basis and regulation of OTULIN-LUBAC interaction

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The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked "linear" Ub chains that regulate the activation of the nuclear factor κB (NFκB) transcription factor and other processes. We recently discovered OTULIN as a deubiquitinase that specifically cleaves Met1-linked p...

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Bibliografiska uppgifter
Huvudupphovsmän:	Elliott, P, Nielsen, S, Marco-Casanova, P, Fiil, B, Keusekotten, K, Mailand, N, Freund, S, Gyrd-Hansen, M, Komander, D
Materialtyp:	Journal article
Språk:	English
Publicerad:	Cell Press 2014

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