Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals.
BACKGROUND: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.OBJECTIVE: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Society for Nutrition
2014
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| _version_ | 1797052010250371072 |
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| author | Clarke, R Bennett, D Parish, S Lewington, S Skeaff, M Eussen, S Lewerin, C Stott, D Armitage, J Hankey, G Lonn, E Spence, J Galan, P de Groot, L Halsey, J Dangour, A Collins, R Grodstein, F |
| author_facet | Clarke, R Bennett, D Parish, S Lewington, S Skeaff, M Eussen, S Lewerin, C Stott, D Armitage, J Hankey, G Lonn, E Spence, J Galan, P de Groot, L Halsey, J Dangour, A Collins, R Grodstein, F |
| author_sort | Clarke, R |
| collection | OXFORD |
| description | BACKGROUND: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.OBJECTIVE: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.DESIGN: A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based z scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE)-type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals).RESULTS: : The domain-composite and MMSE-type global cognitive function z scores both decreased with age (mean ± SE: -0.054 ± 0.004 and -0.036 ± 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the z score differences from baseline for individual domains or for global cognitive function (z score difference: 0.00; 95% CI: -0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (z score difference: -0.01; 95% CI: -0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: -0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment.CONCLUSION: Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging. |
| first_indexed | 2024-03-06T18:27:00Z |
| format | Journal article |
| id | oxford-uuid:084dcf3c-b257-4f80-b977-82dc18a59d89 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:27:00Z |
| publishDate | 2014 |
| publisher | American Society for Nutrition |
| record_format | dspace |
| spelling | oxford-uuid:084dcf3c-b257-4f80-b977-82dc18a59d892022-03-26T09:12:11ZEffects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:084dcf3c-b257-4f80-b977-82dc18a59d89EnglishSymplectic Elements at OxfordAmerican Society for Nutrition2014Clarke, RBennett, DParish, SLewington, SSkeaff, MEussen, SLewerin, CStott, DArmitage, JHankey, GLonn, ESpence, JGalan, Pde Groot, LHalsey, JDangour, ACollins, RGrodstein, FBACKGROUND: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.OBJECTIVE: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.DESIGN: A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based z scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE)-type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals).RESULTS: : The domain-composite and MMSE-type global cognitive function z scores both decreased with age (mean ± SE: -0.054 ± 0.004 and -0.036 ± 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the z score differences from baseline for individual domains or for global cognitive function (z score difference: 0.00; 95% CI: -0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (z score difference: -0.01; 95% CI: -0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: -0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment.CONCLUSION: Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging. |
| spellingShingle | Clarke, R Bennett, D Parish, S Lewington, S Skeaff, M Eussen, S Lewerin, C Stott, D Armitage, J Hankey, G Lonn, E Spence, J Galan, P de Groot, L Halsey, J Dangour, A Collins, R Grodstein, F Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. |
| title | Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. |
| title_full | Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. |
| title_fullStr | Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. |
| title_full_unstemmed | Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. |
| title_short | Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. |
| title_sort | effects of homocysteine lowering with b vitamins on cognitive aging meta analysis of 11 trials with cognitive data on 22 000 individuals |
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