The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni
Monitoring and evaluation (M&E;) programmes are used to collect data which are required to assess the impact of current interventions on their progress towards achieving the World Health Organization (WHO) goals of morbidity control and elimination as a public health problem for schistosomia...
| Những tác giả chính: | , , , , , , , , |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
Public Library of Science
2018
|
| _version_ | 1826258009173524480 |
|---|---|
| author | Toor, J Turner, H Truscott, J Werkman, M Phillips, A Alsallaq, R Medley, G King, C Anderson, R |
| author_facet | Toor, J Turner, H Truscott, J Werkman, M Phillips, A Alsallaq, R Medley, G King, C Anderson, R |
| author_sort | Toor, J |
| collection | OXFORD |
| description | Monitoring and evaluation (M&E;) programmes are used to collect data which are required to assess the impact of current interventions on their progress towards achieving the World Health Organization (WHO) goals of morbidity control and elimination as a public health problem for schistosomiasis. Prevalence and intensity of infection data are typically collected from school-aged children (SAC) as they are relatively easy to sample and are thought to be most likely to be infected by schistosome parasites. However, adults are also likely to be infected. We use three different age-intensity profiles of infection for Schistosoma mansoni with low, moderate and high burdens of infection in adults to investigate how the age distribution of infection impacts the mathematical model generated recommendations of the preventive chemotherapy coverage levels required to achieve the WHO goals. We find that for moderate prevalence regions, regardless of the burden of infection in adults, treating SAC only may achieve the WHO goals. However, for high prevalence regions with a high burden of infection in adults, adult treatment is required to meet the WHO goals. Hence, we show that the optimal treatment strategy for a defined region requires consideration of the burden of infection in adults as it cannot be based solely on the prevalence of infection in SAC. Although past epidemiological data have informed mathematical models for the transmission and control of schistosome infections, more accurate and detailed data are required from M&E; programmes to accurately determine the optimal treatment strategy for a defined region. We highlight the importance of collecting prevalence and intensity of infection data from a broader age-range, specifically the inclusion of adult data at baseline (prior to treatment) and throughout the treatment programme if possible, rather than SAC only, to accurately determine the treatment strategy for a defined region. Furthermore, we discuss additional epidemiological data, such as individual longitudinal adherence to treatment, that should ideally be collected in M&E; programmes. |
| first_indexed | 2024-03-06T18:27:14Z |
| format | Journal article |
| id | oxford-uuid:08652fbe-a23c-4443-8264-0ac3e69e4bb5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:27:14Z |
| publishDate | 2018 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:08652fbe-a23c-4443-8264-0ac3e69e4bb52022-03-26T09:12:39ZThe design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoniJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:08652fbe-a23c-4443-8264-0ac3e69e4bb5EnglishSymplectic Elements at OxfordPublic Library of Science2018Toor, JTurner, HTruscott, JWerkman, MPhillips, AAlsallaq, RMedley, GKing, CAnderson, RMonitoring and evaluation (M&E;) programmes are used to collect data which are required to assess the impact of current interventions on their progress towards achieving the World Health Organization (WHO) goals of morbidity control and elimination as a public health problem for schistosomiasis. Prevalence and intensity of infection data are typically collected from school-aged children (SAC) as they are relatively easy to sample and are thought to be most likely to be infected by schistosome parasites. However, adults are also likely to be infected. We use three different age-intensity profiles of infection for Schistosoma mansoni with low, moderate and high burdens of infection in adults to investigate how the age distribution of infection impacts the mathematical model generated recommendations of the preventive chemotherapy coverage levels required to achieve the WHO goals. We find that for moderate prevalence regions, regardless of the burden of infection in adults, treating SAC only may achieve the WHO goals. However, for high prevalence regions with a high burden of infection in adults, adult treatment is required to meet the WHO goals. Hence, we show that the optimal treatment strategy for a defined region requires consideration of the burden of infection in adults as it cannot be based solely on the prevalence of infection in SAC. Although past epidemiological data have informed mathematical models for the transmission and control of schistosome infections, more accurate and detailed data are required from M&E; programmes to accurately determine the optimal treatment strategy for a defined region. We highlight the importance of collecting prevalence and intensity of infection data from a broader age-range, specifically the inclusion of adult data at baseline (prior to treatment) and throughout the treatment programme if possible, rather than SAC only, to accurately determine the treatment strategy for a defined region. Furthermore, we discuss additional epidemiological data, such as individual longitudinal adherence to treatment, that should ideally be collected in M&E; programmes. |
| spellingShingle | Toor, J Turner, H Truscott, J Werkman, M Phillips, A Alsallaq, R Medley, G King, C Anderson, R The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni |
| title | The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni |
| title_full | The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni |
| title_fullStr | The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni |
| title_full_unstemmed | The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni |
| title_short | The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni |
| title_sort | design of schistosomiasis monitoring and evaluation programmes the importance of collecting adult data to inform treatment strategies for schistosoma mansoni |
| work_keys_str_mv | AT toorj thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT turnerh thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT truscottj thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT werkmanm thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT phillipsa thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT alsallaqr thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT medleyg thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT kingc thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT andersonr thedesignofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT toorj designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT turnerh designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT truscottj designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT werkmanm designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT phillipsa designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT alsallaqr designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT medleyg designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT kingc designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni AT andersonr designofschistosomiasismonitoringandevaluationprogrammestheimportanceofcollectingadultdatatoinformtreatmentstrategiesforschistosomamansoni |