Fluorine in medicinal chemistry.
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826258011525480448 |
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| author | Purser, S Moore, P Swallow, S Gouverneur, V |
| author_facet | Purser, S Moore, P Swallow, S Gouverneur, V |
| author_sort | Purser, S |
| collection | OXFORD |
| description | It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency. |
| first_indexed | 2024-03-06T18:27:16Z |
| format | Journal article |
| id | oxford-uuid:0869251e-0aeb-482f-8b46-1c3105ca2958 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:27:16Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:0869251e-0aeb-482f-8b46-1c3105ca29582022-03-26T09:12:43ZFluorine in medicinal chemistry.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0869251e-0aeb-482f-8b46-1c3105ca2958EnglishSymplectic Elements at Oxford2008Purser, SMoore, PSwallow, SGouverneur, VIt has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency. |
| spellingShingle | Purser, S Moore, P Swallow, S Gouverneur, V Fluorine in medicinal chemistry. |
| title | Fluorine in medicinal chemistry. |
| title_full | Fluorine in medicinal chemistry. |
| title_fullStr | Fluorine in medicinal chemistry. |
| title_full_unstemmed | Fluorine in medicinal chemistry. |
| title_short | Fluorine in medicinal chemistry. |
| title_sort | fluorine in medicinal chemistry |
| work_keys_str_mv | AT pursers fluorineinmedicinalchemistry AT moorep fluorineinmedicinalchemistry AT swallows fluorineinmedicinalchemistry AT gouverneurv fluorineinmedicinalchemistry |