Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.
OBJECTIVE: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). METHODS: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published T...
| Հիմնական հեղինակներ: | , , , , , , , , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
2008
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| _version_ | 1826258032929013760 |
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| author | Pointon, J Chapman, K Harvey, D Sims, A Bradbury, L Laiho, K Kauppi, M Kaarela, K Tuomilehto, J Brown, M Wordsworth, B |
| author_facet | Pointon, J Chapman, K Harvey, D Sims, A Bradbury, L Laiho, K Kauppi, M Kaarela, K Tuomilehto, J Brown, M Wordsworth, B |
| author_sort | Pointon, J |
| collection | OXFORD |
| description | OBJECTIVE: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). METHODS: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. RESULTS: In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. CONCLUSION: CD14 and TLR4 showed an association with AS in the Finns only. |
| first_indexed | 2024-03-06T18:27:36Z |
| format | Journal article |
| id | oxford-uuid:08855b07-521e-4e63-a193-82fe0daffc08 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:27:36Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:08855b07-521e-4e63-a193-82fe0daffc082022-03-26T09:13:18ZToll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:08855b07-521e-4e63-a193-82fe0daffc08EnglishSymplectic Elements at Oxford2008Pointon, JChapman, KHarvey, DSims, ABradbury, LLaiho, KKauppi, MKaarela, KTuomilehto, JBrown, MWordsworth, B OBJECTIVE: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). METHODS: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. RESULTS: In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. CONCLUSION: CD14 and TLR4 showed an association with AS in the Finns only. |
| spellingShingle | Pointon, J Chapman, K Harvey, D Sims, A Bradbury, L Laiho, K Kauppi, M Kaarela, K Tuomilehto, J Brown, M Wordsworth, B Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. |
| title | Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. |
| title_full | Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. |
| title_fullStr | Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. |
| title_full_unstemmed | Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. |
| title_short | Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns. |
| title_sort | toll like receptor 4 and cd14 polymorphisms in ankylosing spondylitis evidence of a weak association in finns |
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