ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has gro...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2017
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| _version_ | 1797052071102382080 |
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| author | Blackford, A Jackson, S |
| author_facet | Blackford, A Jackson, S |
| author_sort | Blackford, A |
| collection | OXFORD |
| description | In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities and common mechanisms of regulation, as well as emerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health. |
| first_indexed | 2024-03-06T18:27:38Z |
| format | Journal article |
| id | oxford-uuid:08865817-a929-480c-b0ab-8ce634ebaf16 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:27:38Z |
| publishDate | 2017 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:08865817-a929-480c-b0ab-8ce634ebaf162022-03-26T09:13:21ZATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage responseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:08865817-a929-480c-b0ab-8ce634ebaf16EnglishSymplectic Elements at OxfordCell Press2017Blackford, AJackson, SIn vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities and common mechanisms of regulation, as well as emerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health. |
| spellingShingle | Blackford, A Jackson, S ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response |
| title | ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response |
| title_full | ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response |
| title_fullStr | ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response |
| title_full_unstemmed | ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response |
| title_short | ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response |
| title_sort | atm atr and dna pk the trinity at the heart of the dna damage response |
| work_keys_str_mv | AT blackforda atmatranddnapkthetrinityattheheartofthednadamageresponse AT jacksons atmatranddnapkthetrinityattheheartofthednadamageresponse |