Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

The opportunistic pathogen Pseudomonas aeruginosa produces colorful redox-active metabolites called phenazines, which underpin biofilm development, virulence and clinical outcomes. Though phenazines exist in many forms, the best studied is pyocyanin. Here, we describe pyocyanin demethylase (PodA), a...

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Hlavní autoři: Costa, K, Glasser, N, Conway, S, Newman, D
Médium: Journal article
Jazyk:English
Vydáno: American Association for the Advancement of Science 2017