Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.

Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.

beta-catenin is involved in E-cadherin-mediated cell adhesion, intracellular signal transduction, and also interacts with adenomatous polyposis coli (APC) protein. We previously found that 31% of colorectal adenomas and 84% of carcinomas showed reduced membranous staining of beta-catenin, while 46%...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Hao, X, Frayling, I, Willcocks, T, Han, W, Tomlinson, I, Pignatelli, M, Pretlow, T, Talbot, I
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2002

Gelijkaardige items

Loss of heterozygosity at APC and beta-catenin expression in sporadic colorectal carcinogenesis
door: Hao, X, et al.
Gepubliceerd in: (1998)

β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC
door: Ernst Fredericks, et al.
Gepubliceerd in: (2018-01-01)

Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.
door: Homfray, T, et al.
Gepubliceerd in: (1998)

The interactions of APC, E-cadherin and beta-catenin in tumour development and progression.
door: Ilyas, M, et al.
Gepubliceerd in: (1997)

Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis.
door: Tomlinson, I, et al.
Gepubliceerd in: (1996)

Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours.
door: Hao, X, et al.
Gepubliceerd in: (1997)

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.
door: Frayling, I, et al.
Gepubliceerd in: (1997)

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.
door: Christie, M, et al.
Gepubliceerd in: (2013)

Beta-catenin mutations in cell lines established from human colorectal cancers.
door: Ilyas, M, et al.
Gepubliceerd in: (1997)

The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas.
door: Hao, X, et al.
Gepubliceerd in: (2002)

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
door: Rowan, A, et al.
Gepubliceerd in: (2000)

The low frequency of beta-catenin mutations in cell lines established from human colorectal cancers
door: Ilyas, M, et al.
Gepubliceerd in: (1997)

Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers.
door: Ilyas, M, et al.
Gepubliceerd in: (1997)

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
door: Tomlinson, I, et al.
Gepubliceerd in: (1996)

Germline APC mutations are not commonly seen in children with sporadic hepatoblastoma.
door: Harvey, J, et al.
Gepubliceerd in: (2008)

APC mutations are sufficient for the growth of early colorectal adenomas.
door: Lamlum, H, et al.
Gepubliceerd in: (2000)

Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation
door: Schneikert, Jean, et al.
Gepubliceerd in: (2013)

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.
door: Jean Schneikert, et al.
Gepubliceerd in: (2013-01-01)

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
door: Pollard, P, et al.
Gepubliceerd in: (2009)

Different pathways of colorectal carcinogenesis and their clinical pictures.
door: Tomlinson, I
Gepubliceerd in: (2000)

Frequent alteration of the tumor suppressor gene APC in sporadic canine colorectal tumors.
door: Lydia Youmans, et al.
Gepubliceerd in: (2012-01-01)

The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
door: Frayling, I, et al.
Gepubliceerd in: (1998)

Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.
door: Hao, X, et al.
Gepubliceerd in: (1997)

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
door: Segditsas, S, et al.
Gepubliceerd in: (2008)

Refining molecular analysis in the pathways of colorectal carcinogenesis.
door: Rowan, A, et al.
Gepubliceerd in: (2005)

Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome.
door: Johnson, V, et al.
Gepubliceerd in: (2005)

Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.
door: Suraweera, N, et al.
Gepubliceerd in: (2006)

Association between cigarette smoking, <it>APC </it>mutations and the risk of developing sporadic colorectal adenomas and carcinomas
door: Hagen Per, et al.
Gepubliceerd in: (2006-03-01)

Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
door: Guifeng Su, et al.
Gepubliceerd in: (2024-02-01)

Bcl-2 expression in colorectal tumors: evidence of different pathways in sporadic and ulcerative-colitis-associated carcinomas.
door: Ilyas, M, et al.
Gepubliceerd in: (1996)

APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps.
door: Will, O, et al.
Gepubliceerd in: (2008)

Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract
door: Zauber, P, et al.
Gepubliceerd in: (2014)

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
door: Wang, Z, et al.
Gepubliceerd in: (1999)

Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability.
door: Ilyas, M, et al.
Gepubliceerd in: (1996)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
door: Thirlwell, C, et al.
Gepubliceerd in: (2007)

β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.
door: Mohamed Bourmoum, et al.
Gepubliceerd in: (2024-01-01)

β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53
door: Mohamed Bourmoum, et al.
Gepubliceerd in: (2024-01-01)

Germline epimutations of APC are not associated with inherited colorectal polyposis.
door: Hitchins, M, et al.
Gepubliceerd in: (2006)

Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma.
door: Fodde, R, et al.
Gepubliceerd in: (2010)

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?
door: Sieber, O, et al.
Gepubliceerd in: (2003)