Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation

<p>Local hypoxia occurs in most solid tumors and is associated with aggressive disease and therapy resistance. Widespread changes in gene expression play a critical role in the biological response to hypoxia. However, most research has focused on hypoxia-inducible genes as opposed to those tha...

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Main Authors: Leszczynka, K, Dzwigonska, M, Estephan, H, Moehlenbrink, J, Bowler, E, Giaccia, A, Mieczkowski, J, Kaminska, B, Hammond, E
格式: Journal article
语言:English
出版: Wiley 2023