Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States.
During the past 6 to 7 years, the problem of antimicrobial resistance in Streptococcus pneumoniae has grown dramatically in the United States. Currently, approximately 26.5% of pneumococcal isolates express intermediate levels of resistance to penicillin; approximately 17.5% are highly penicillin re...
| Hoofdauteurs: | , , , , , , , , , , |
|---|---|
| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
1998
|
| _version_ | 1826258163053101056 |
|---|---|
| author | Doern, G Brueggemann, A Blocker, M Dunne, M Holley, H Kehl, K Duval, J Kugler, K Putnam, S Rauch, A Pfaller, M |
| author_facet | Doern, G Brueggemann, A Blocker, M Dunne, M Holley, H Kehl, K Duval, J Kugler, K Putnam, S Rauch, A Pfaller, M |
| author_sort | Doern, G |
| collection | OXFORD |
| description | During the past 6 to 7 years, the problem of antimicrobial resistance in Streptococcus pneumoniae has grown dramatically in the United States. Currently, approximately 26.5% of pneumococcal isolates express intermediate levels of resistance to penicillin; approximately 17.5% are highly penicillin resistant. We studied whether clonal relationships exist among current isolates of high-level penicillin-resistant S. pneumoniae (PRSP) in the United States. One hundred forty-seven PRSP isolates recovered in a 30-center surveillance study in the United States during 1994-1995 were characterized with respect to serotype, antimicrobial susceptibility pattern, and pulsed-field gel electrophoresis (PFGE) profile. Only six serotypes were observed among the 147 PRSP isolates examined in this study: 6A, 6B, 9A, 14, 19F, and 23F. One hundred three (70.1%) of the 147 strains were characterized by one of only nine PFGE types; 76 (51.7%) of the 147 isolates were characterized by only four PFGE profiles. Currently in the United States, most PRSP strains are represented by relatively few clonal groups. |
| first_indexed | 2024-03-06T18:29:40Z |
| format | Journal article |
| id | oxford-uuid:0935d011-2ecc-47fe-bc20-33a4a0658b2b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:29:40Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:0935d011-2ecc-47fe-bc20-33a4a0658b2b2022-03-26T09:17:04ZClonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0935d011-2ecc-47fe-bc20-33a4a0658b2bEnglishSymplectic Elements at Oxford1998Doern, GBrueggemann, ABlocker, MDunne, MHolley, HKehl, KDuval, JKugler, KPutnam, SRauch, APfaller, MDuring the past 6 to 7 years, the problem of antimicrobial resistance in Streptococcus pneumoniae has grown dramatically in the United States. Currently, approximately 26.5% of pneumococcal isolates express intermediate levels of resistance to penicillin; approximately 17.5% are highly penicillin resistant. We studied whether clonal relationships exist among current isolates of high-level penicillin-resistant S. pneumoniae (PRSP) in the United States. One hundred forty-seven PRSP isolates recovered in a 30-center surveillance study in the United States during 1994-1995 were characterized with respect to serotype, antimicrobial susceptibility pattern, and pulsed-field gel electrophoresis (PFGE) profile. Only six serotypes were observed among the 147 PRSP isolates examined in this study: 6A, 6B, 9A, 14, 19F, and 23F. One hundred three (70.1%) of the 147 strains were characterized by one of only nine PFGE types; 76 (51.7%) of the 147 isolates were characterized by only four PFGE profiles. Currently in the United States, most PRSP strains are represented by relatively few clonal groups. |
| spellingShingle | Doern, G Brueggemann, A Blocker, M Dunne, M Holley, H Kehl, K Duval, J Kugler, K Putnam, S Rauch, A Pfaller, M Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. |
| title | Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. |
| title_full | Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. |
| title_fullStr | Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. |
| title_full_unstemmed | Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. |
| title_short | Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. |
| title_sort | clonal relationships among high level penicillin resistant streptococcus pneumoniae in the united states |
| work_keys_str_mv | AT doerng clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT brueggemanna clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT blockerm clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT dunnem clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT holleyh clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT kehlk clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT duvalj clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT kuglerk clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT putnams clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT raucha clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates AT pfallerm clonalrelationshipsamonghighlevelpenicillinresistantstreptococcuspneumoniaeintheunitedstates |