Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac fu...
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
Springer Nature
2023
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