Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac fu...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Park, KC, Crump, NT, Louwman, N, Krywawych, S, Choeng, YJ, Vendrell, I, Gill, EK, Gunadasa-Rohling, M, Ford, KL, Hauton, D, Fournier, M, Pires, E, Watson, L, Roseman, G, Holder, J, Koschinski, A, Carnicer, R, Curtis, MK, Zaccolo, M, Hulikova, A, Fischer, R, Kramer, HB, McCullagh, JSO, Trefely, S, Milne, TA, Swietach, P
Format:	Journal article
Język:	English
Wydane:	Springer Nature 2023

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