Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
Antigen presentation is a key rate-limiting step in the immune response. Dendritic cells (DCs) have been reported to be the most potent antigen-presenting cells for naïve T cells, but little is known about the biochemical pathways that regulate this function. We here demonstrate that mature murine D...
Main Authors: | Yoshimura, S, Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2003
|
Similar Items
-
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
by: Yoshimura, S, et al.
Published: (2001) -
Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.
by: Yoshimura, S, et al.
Published: (2001) -
Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
by: Calder, V, et al.
Published: (2003) -
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
by: Bondeson, J, et al.
Published: (2000) -
Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
by: Bondeson, J, et al.
Published: (1999)