Vaccines that stimulate T cell immunity to HIV-1: the next step.
The search for a vaccine against human immunodeficiency virus type 1 (HIV-1) has many hurdles to overcome. Ideally, the stimulation of both broadly neutralizing antibodies and cell-mediated immune responses remains the best option, but no candidate in clinical trials at present has elicited such ant...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797052397938278400 |
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| author | Mcmichael, A Koff, W |
| author_facet | Mcmichael, A Koff, W |
| author_sort | Mcmichael, A |
| collection | OXFORD |
| description | The search for a vaccine against human immunodeficiency virus type 1 (HIV-1) has many hurdles to overcome. Ideally, the stimulation of both broadly neutralizing antibodies and cell-mediated immune responses remains the best option, but no candidate in clinical trials at present has elicited such antibodies, and efficacy trials have not demonstrated any benefit for vaccines designed to stimulate immune responses of CD8(+) T cells. Findings obtained with the simian immunodeficiency virus (SIV) monkey model have provided new evidence that stimulating effective CD8(+) T cell immunity could provide protection, and in this Perspective we explore the path forward for optimizing such responses in humans. |
| first_indexed | 2024-03-06T18:31:03Z |
| format | Journal article |
| id | oxford-uuid:09ab72e9-53ae-48b7-be19-ab72ab1fc811 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:31:03Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:09ab72e9-53ae-48b7-be19-ab72ab1fc8112022-03-26T09:19:33ZVaccines that stimulate T cell immunity to HIV-1: the next step.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:09ab72e9-53ae-48b7-be19-ab72ab1fc811EnglishSymplectic Elements at Oxford2014Mcmichael, AKoff, WThe search for a vaccine against human immunodeficiency virus type 1 (HIV-1) has many hurdles to overcome. Ideally, the stimulation of both broadly neutralizing antibodies and cell-mediated immune responses remains the best option, but no candidate in clinical trials at present has elicited such antibodies, and efficacy trials have not demonstrated any benefit for vaccines designed to stimulate immune responses of CD8(+) T cells. Findings obtained with the simian immunodeficiency virus (SIV) monkey model have provided new evidence that stimulating effective CD8(+) T cell immunity could provide protection, and in this Perspective we explore the path forward for optimizing such responses in humans. |
| spellingShingle | Mcmichael, A Koff, W Vaccines that stimulate T cell immunity to HIV-1: the next step. |
| title | Vaccines that stimulate T cell immunity to HIV-1: the next step. |
| title_full | Vaccines that stimulate T cell immunity to HIV-1: the next step. |
| title_fullStr | Vaccines that stimulate T cell immunity to HIV-1: the next step. |
| title_full_unstemmed | Vaccines that stimulate T cell immunity to HIV-1: the next step. |
| title_short | Vaccines that stimulate T cell immunity to HIV-1: the next step. |
| title_sort | vaccines that stimulate t cell immunity to hiv 1 the next step |
| work_keys_str_mv | AT mcmichaela vaccinesthatstimulatetcellimmunitytohiv1thenextstep AT koffw vaccinesthatstimulatetcellimmunitytohiv1thenextstep |