A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
Prolyl hydroxylation domain (PHD) enzymes catalyze the hydroxylation of the transcription factor hypoxia‐inducible factor (HIF) and serve as cellular oxygen sensors. HIF and the PHD enzymes regulate numerous potentially tissue‐protective target genes which can adapt cells to metabolic and ischemic s...
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| Main Authors: |
Mayer, M,
Fey, K,
Heinze, E,
Rainer Wick, C,
Abboud, M,
Yeh, T,
Tumber, A,
Orth, N,
Schley, G,
Buchholz, B,
Clark, T,
Schofield, C,
Willam, C,
Burzlaff, N |
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| 格式: | Journal article
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| 出版: |
Wiley
2018
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