A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

Prolyl hydroxylation domain (PHD) enzymes catalyze the hydroxylation of the transcription factor hypoxia‐inducible factor (HIF) and serve as cellular oxygen sensors. HIF and the PHD enzymes regulate numerous potentially tissue‐protective target genes which can adapt cells to metabolic and ischemic s...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Mayer, M, Fey, K, Heinze, E, Rainer Wick, C, Abboud, M, Yeh, T, Tumber, A, Orth, N, Schley, G, Buchholz, B, Clark, T, Schofield, C, Willam, C, Burzlaff, N
Μορφή:	Journal article
Έκδοση:	Wiley 2018

Παρόμοια τεκμήρια

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
ανά: Andrea Hartner, κ.ά.
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Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
ανά: Chan, M, κ.ά.
Έκδοση: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
ανά: Yeh, TL, κ.ά.
Έκδοση: (2017)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
ανά: McNeill, L, κ.ά.
Έκδοση: (2002)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
ανά: Mole, D, κ.ά.
Έκδοση: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
ανά: Cockman, M, κ.ά.
Έκδοση: (2019)

Regulation of HIF: prolyl hydroxylases.
ανά: Stolze, I, κ.ά.
Έκδοση: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
ανά: Chowdhury, R, κ.ά.
Έκδοση: (2016)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
ανά: Schlemminger, I, κ.ά.
Έκδοση: (2003)

Inhibition of a viral prolyl hydroxylase
ανά: Langley, G, κ.ά.
Έκδοση: (2019)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
ανά: Chowdhury, R, κ.ά.
Έκδοση: (2013)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
ανά: Matthew E Cockman, κ.ά.
Έκδοση: (2019-09-01)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
ανά: Holt-Martyn, JP, κ.ά.
Έκδοση: (2019)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
ανά: Lippl, K, κ.ά.
Έκδοση: (2015)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
ανά: Rasheduzzaman Chowdhury, κ.ά.
Έκδοση: (2016-08-01)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
ανά: Tuckerman, JR, κ.ά.
Έκδοση: (2004)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
ανά: Willam, C, κ.ά.
Έκδοση: (2006)

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
ανά: Thinnes, C, κ.ά.
Έκδοση: (2018)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
ανά: Chen, R, κ.ά.
Έκδοση: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
ανά: Chen, R, κ.ά.
Έκδοση: (2014)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
ανά: Flashman, E, κ.ά.
Έκδοση: (2010)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
ανά: Moritz J. Strowitzki, κ.ά.
Έκδοση: (2021-04-01)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
ανά: Astuti, D, κ.ά.
Έκδοση: (2010)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
ανά: Masson, N, κ.ά.
Έκδοση: (2003)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
ανά: Holt-Martyn, J, κ.ά.
Έκδοση: (2019)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
ανά: Masson, N, κ.ά.
Έκδοση: (2004)

Prolyl hydroxylases and therapeutics.
ανά: Smith, T, κ.ά.
Έκδοση: (2010)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
ανά: Wijeyekoon, JB
Έκδοση: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
ανά: Maria Savyuk, κ.ά.
Έκδοση: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
ανά: Andrey A. Poloznikov, κ.ά.
Έκδοση: (2021-01-01)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
ανά: Singh, A, κ.ά.
Έκδοση: (2020)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
ανά: Yeoh, K, κ.ά.
Έκδοση: (2013)

Oxygen sensing by HIF hydroxylases.
ανά: Schofield, C, κ.ά.
Έκδοση: (2004)

Signalling hypoxia by HIF hydroxylases.
ανά: Schofield, C, κ.ά.
Έκδοση: (2005)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
ανά: Abboud, M, κ.ά.
Έκδοση: (2018)

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
ανά: Richardson, NL, κ.ά.
Έκδοση: (2021)

Therapeutic manipulation of the HIF hydroxylases.
ανά: Nagel, S, κ.ά.
Έκδοση: (2010)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
ανά: Mecinovic, J, κ.ά.
Έκδοση: (2007)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
ανά: Lippl, K
Έκδοση: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
ανά: Takahiro Kambara, κ.ά.
Έκδοση: (2024-03-01)