A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

Prolyl hydroxylation domain (PHD) enzymes catalyze the hydroxylation of the transcription factor hypoxia‐inducible factor (HIF) and serve as cellular oxygen sensors. HIF and the PHD enzymes regulate numerous potentially tissue‐protective target genes which can adapt cells to metabolic and ischemic s...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Mayer, M, Fey, K, Heinze, E, Rainer Wick, C, Abboud, M, Yeh, T, Tumber, A, Orth, N, Schley, G, Buchholz, B, Clark, T, Schofield, C, Willam, C, Burzlaff, N
Formato:	Journal article
Publicado em:	Wiley 2018

Registros relacionados

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
por: Andrea Hartner, et al.
Publicado em: (2023-06-01)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
por: Chan, M, et al.
Publicado em: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
por: Yeh, TL, et al.
Publicado em: (2017)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
por: McNeill, L, et al.
Publicado em: (2002)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
por: Mole, D, et al.
Publicado em: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Cockman, M, et al.
Publicado em: (2019)

Regulation of HIF: prolyl hydroxylases.
por: Stolze, I, et al.
Publicado em: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
por: Chowdhury, R, et al.
Publicado em: (2016)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
por: Schlemminger, I, et al.
Publicado em: (2003)

Inhibition of a viral prolyl hydroxylase
por: Langley, G, et al.
Publicado em: (2019)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
por: Chowdhury, R, et al.
Publicado em: (2013)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Matthew E Cockman, et al.
Publicado em: (2019-09-01)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
por: Holt-Martyn, JP, et al.
Publicado em: (2019)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
por: Lippl, K, et al.
Publicado em: (2015)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
por: Rasheduzzaman Chowdhury, et al.
Publicado em: (2016-08-01)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
por: Tuckerman, JR, et al.
Publicado em: (2004)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
por: Willam, C, et al.
Publicado em: (2006)

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
por: Thinnes, C, et al.
Publicado em: (2018)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
por: Chen, R, et al.
Publicado em: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
por: Chen, R, et al.
Publicado em: (2014)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
por: Flashman, E, et al.
Publicado em: (2010)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
por: Moritz J. Strowitzki, et al.
Publicado em: (2021-04-01)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
por: Astuti, D, et al.
Publicado em: (2010)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
por: Masson, N, et al.
Publicado em: (2003)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
por: Holt-Martyn, J, et al.
Publicado em: (2019)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
por: Masson, N, et al.
Publicado em: (2004)

Prolyl hydroxylases and therapeutics.
por: Smith, T, et al.
Publicado em: (2010)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
por: Wijeyekoon, JB
Publicado em: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
por: Maria Savyuk, et al.
Publicado em: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
por: Andrey A. Poloznikov, et al.
Publicado em: (2021-01-01)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
por: Singh, A, et al.
Publicado em: (2020)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
por: Yeoh, K, et al.
Publicado em: (2013)

Oxygen sensing by HIF hydroxylases.
por: Schofield, C, et al.
Publicado em: (2004)

Signalling hypoxia by HIF hydroxylases.
por: Schofield, C, et al.
Publicado em: (2005)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
por: Abboud, M, et al.
Publicado em: (2018)

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
por: Richardson, NL, et al.
Publicado em: (2021)

Therapeutic manipulation of the HIF hydroxylases.
por: Nagel, S, et al.
Publicado em: (2010)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
por: Mecinovic, J, et al.
Publicado em: (2007)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
por: Lippl, K
Publicado em: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
por: Takahiro Kambara, et al.
Publicado em: (2024-03-01)