A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

Prolyl hydroxylation domain (PHD) enzymes catalyze the hydroxylation of the transcription factor hypoxia‐inducible factor (HIF) and serve as cellular oxygen sensors. HIF and the PHD enzymes regulate numerous potentially tissue‐protective target genes which can adapt cells to metabolic and ischemic s...

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Bibliografiska uppgifter
Huvudupphovsmän:	Mayer, M, Fey, K, Heinze, E, Rainer Wick, C, Abboud, M, Yeh, T, Tumber, A, Orth, N, Schley, G, Buchholz, B, Clark, T, Schofield, C, Willam, C, Burzlaff, N
Materialtyp:	Journal article
Publicerad:	Wiley 2018

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av: Chan, M, et al.
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av: Yeh, TL, et al.
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av: McNeill, L, et al.
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2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
av: Mole, D, et al.
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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
av: Cockman, M, et al.
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Regulation of HIF: prolyl hydroxylases.
av: Stolze, I, et al.
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av: Chowdhury, R, et al.
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av: Schlemminger, I, et al.
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Inhibition of a viral prolyl hydroxylase
av: Langley, G, et al.
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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
av: Chowdhury, R, et al.
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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
av: Matthew E Cockman, et al.
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Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
av: Holt-Martyn, JP, et al.
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av: Lippl, K, et al.
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
av: Rasheduzzaman Chowdhury, et al.
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Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
av: Tuckerman, JR, et al.
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HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
av: Willam, C, et al.
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Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
av: Thinnes, C, et al.
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HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
av: Chen, R, et al.
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HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
av: Chen, R, et al.
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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
av: Flashman, E, et al.
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av: Moritz J. Strowitzki, et al.
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Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
av: Astuti, D, et al.
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HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
av: Masson, N, et al.
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Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
av: Holt-Martyn, J, et al.
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The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
av: Masson, N, et al.
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Prolyl hydroxylases and therapeutics.
av: Smith, T, et al.
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Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
av: Wijeyekoon, JB
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av: Maria Savyuk, et al.
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av: Singh, A, et al.
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Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
av: Yeoh, K, et al.
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Oxygen sensing by HIF hydroxylases.
av: Schofield, C, et al.
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Signalling hypoxia by HIF hydroxylases.
av: Schofield, C, et al.
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Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
av: Abboud, M, et al.
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Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
av: Richardson, NL, et al.
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Therapeutic manipulation of the HIF hydroxylases.
av: Nagel, S, et al.
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Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
av: Mecinovic, J, et al.
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Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
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