A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging

Prolyl hydroxylation domain (PHD) enzymes catalyze the hydroxylation of the transcription factor hypoxia‐inducible factor (HIF) and serve as cellular oxygen sensors. HIF and the PHD enzymes regulate numerous potentially tissue‐protective target genes which can adapt cells to metabolic and ischemic s...

Detaylı Bibliyografya
Asıl Yazarlar:	Mayer, M, Fey, K, Heinze, E, Rainer Wick, C, Abboud, M, Yeh, T, Tumber, A, Orth, N, Schley, G, Buchholz, B, Clark, T, Schofield, C, Willam, C, Burzlaff, N
Materyal Türü:	Journal article
Baskı/Yayın Bilgisi:	Wiley 2018

Benzer Materyaller

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
Yazar:: Andrea Hartner, ve diğerleri
Baskı/Yayın Bilgisi: (2023-06-01)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
Yazar:: Chan, M, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
Yazar:: Yeh, TL, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
Yazar:: McNeill, L, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Yazar:: Mole, D, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Yazar:: Cockman, M, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Regulation of HIF: prolyl hydroxylases.
Yazar:: Stolze, I, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Yazar:: Chowdhury, R, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Yazar:: Schlemminger, I, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Inhibition of a viral prolyl hydroxylase
Yazar:: Langley, G, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Yazar:: Chowdhury, R, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Yazar:: Matthew E Cockman, ve diğerleri
Baskı/Yayın Bilgisi: (2019-09-01)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
Yazar:: Holt-Martyn, JP, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
Yazar:: Lippl, K, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Yazar:: Rasheduzzaman Chowdhury, ve diğerleri
Baskı/Yayın Bilgisi: (2016-08-01)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
Yazar:: Tuckerman, JR, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
Yazar:: Willam, C, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
Yazar:: Thinnes, C, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
Yazar:: Chen, R, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
Yazar:: Chen, R, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
Yazar:: Flashman, E, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
Yazar:: Moritz J. Strowitzki, ve diğerleri
Baskı/Yayın Bilgisi: (2021-04-01)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
Yazar:: Astuti, D, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
Yazar:: Masson, N, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
Yazar:: Holt-Martyn, J, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
Yazar:: Masson, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Prolyl hydroxylases and therapeutics.
Yazar:: Smith, T, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
Yazar:: Wijeyekoon, JB
Baskı/Yayın Bilgisi: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
Yazar:: Maria Savyuk, ve diğerleri
Baskı/Yayın Bilgisi: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
Yazar:: Andrey A. Poloznikov, ve diğerleri
Baskı/Yayın Bilgisi: (2021-01-01)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
Yazar:: Singh, A, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Yazar:: Yeoh, K, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Oxygen sensing by HIF hydroxylases.
Yazar:: Schofield, C, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Signalling hypoxia by HIF hydroxylases.
Yazar:: Schofield, C, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
Yazar:: Abboud, M, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
Yazar:: Richardson, NL, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Therapeutic manipulation of the HIF hydroxylases.
Yazar:: Nagel, S, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
Yazar:: Mecinovic, J, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
Yazar:: Lippl, K
Baskı/Yayın Bilgisi: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
Yazar:: Takahiro Kambara, ve diğerleri
Baskı/Yayın Bilgisi: (2024-03-01)