Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells

Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells

Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomic...

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Bibliographic Details
Main Authors: Artibani, M, Masuda, K, Hu, Z, Rauher, PC, Mallett, G, Wietek, N, Morotti, M, Chong, K, KaramiNejadRanjbar, M, Zois, CE, Dhar, S, El-Sahhar, S, Campo, L, Blagden, SP, Damato, S, Pathiraja, PN, Nicum, S, Gleeson, F, Laios, A, Alsaadi, A, Santana Gonzalez, L, Motohara, T, Albukhari, A, Lu, Z, Bast Jr., RC, Harris, AL, Ejsing, CS, Klemm, RW, Yau, C, Sauka-Spengler, T, Ahmed, AA
Format: Journal article
Language:English
Published: American Society for Clinical Investigation 2021

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