An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand
Background: The aim of this study was to assess the psychometric properties, namely acceptability, validity, reliability, interpretability and responsiveness of the EuroQol EQ-5D (EQ-5D visual analogue (VAS) and EQ-5D (utility)) , Short Form 12 Dimensions (SF-12), SF-6D and Michigan Hand Outcome Que...
| প্রধান লেখক: | , , , |
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| বিন্যাস: | Journal article |
| প্রকাশিত: |
BioMed Central
2017
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| _version_ | 1826258314341646336 |
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| author | Dritsaki, M Petrou, S Williams, M Lamb, S |
| author_facet | Dritsaki, M Petrou, S Williams, M Lamb, S |
| author_sort | Dritsaki, M |
| collection | OXFORD |
| description | Background: The aim of this study was to assess the psychometric properties, namely acceptability, validity, reliability, interpretability and responsiveness of the EuroQol EQ-5D (EQ-5D visual analogue (VAS) and EQ-5D (utility)) , Short Form 12 Dimensions (SF-12), SF-6D and Michigan Hand Outcome Questionnaire (MHQ) in patients with rheumatoid arthritis (RA) of the hand. Methods: The empirical investigation was based upon data from a randomised controlled trial of 488 adults with rheumatoid arthritis who had pain and dysfunction of the hands and/or wrists. Participants completed the EQ-5D, SF-12 and MHQ at baseline and at 4 and 12 months follow up. Acceptability was measured using completion rates over time; construct validity using the “known groups” approach, based on pain troublesomeness; convergent validity using spearman’s rho correlation (ρ); reliability using internal consistency (Cronbach’s alpha); interpretability using minimal important differences (MID); and responsiveness using effect sizes and standardised response means (SRM) stratified by level of self-rated improvement in hand and wrist function or level of self-rated benefit and satisfaction from trial treatments. Results: At baseline, the study population had a mean age of 62.4 years, a mean MHQ score of 52.1 and included 76% women. The EQ-5D (utility) had the highest completion rates across time points. All instruments discriminated between pre-specified groups based on pain troublesomeness. Convergent validity analysis indicated that the MHQ score correlated strongly with the EQ-5D (ρ = 0.65) and SF-6D (ρ = 0.63) utility scores. The MHQ was most responsive at detecting change in indicators of RA pain severity between baseline and 4 months, whilst minimal important differences varied considerably across PROMs. Conclusions: The instruments evaluated in this study displayed varying psychometric properties in the context of RA of the hand. The selection of a preferred instrument in evaluative studies should ultimately depend on the relative importance placed on individual psychometric properties and the importance placed on generation of health utilities for economic evaluation purposes. |
| first_indexed | 2024-03-06T18:32:02Z |
| format | Journal article |
| id | oxford-uuid:09f9772b-4b36-4512-a7f0-d638acf45538 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:32:02Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:09f9772b-4b36-4512-a7f0-d638acf455382022-03-26T09:21:17ZAn empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the handJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:09f9772b-4b36-4512-a7f0-d638acf45538Symplectic Elements at OxfordBioMed Central2017Dritsaki, MPetrou, SWilliams, MLamb, SBackground: The aim of this study was to assess the psychometric properties, namely acceptability, validity, reliability, interpretability and responsiveness of the EuroQol EQ-5D (EQ-5D visual analogue (VAS) and EQ-5D (utility)) , Short Form 12 Dimensions (SF-12), SF-6D and Michigan Hand Outcome Questionnaire (MHQ) in patients with rheumatoid arthritis (RA) of the hand. Methods: The empirical investigation was based upon data from a randomised controlled trial of 488 adults with rheumatoid arthritis who had pain and dysfunction of the hands and/or wrists. Participants completed the EQ-5D, SF-12 and MHQ at baseline and at 4 and 12 months follow up. Acceptability was measured using completion rates over time; construct validity using the “known groups” approach, based on pain troublesomeness; convergent validity using spearman’s rho correlation (ρ); reliability using internal consistency (Cronbach’s alpha); interpretability using minimal important differences (MID); and responsiveness using effect sizes and standardised response means (SRM) stratified by level of self-rated improvement in hand and wrist function or level of self-rated benefit and satisfaction from trial treatments. Results: At baseline, the study population had a mean age of 62.4 years, a mean MHQ score of 52.1 and included 76% women. The EQ-5D (utility) had the highest completion rates across time points. All instruments discriminated between pre-specified groups based on pain troublesomeness. Convergent validity analysis indicated that the MHQ score correlated strongly with the EQ-5D (ρ = 0.65) and SF-6D (ρ = 0.63) utility scores. The MHQ was most responsive at detecting change in indicators of RA pain severity between baseline and 4 months, whilst minimal important differences varied considerably across PROMs. Conclusions: The instruments evaluated in this study displayed varying psychometric properties in the context of RA of the hand. The selection of a preferred instrument in evaluative studies should ultimately depend on the relative importance placed on individual psychometric properties and the importance placed on generation of health utilities for economic evaluation purposes. |
| spellingShingle | Dritsaki, M Petrou, S Williams, M Lamb, S An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand |
| title | An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand |
| title_full | An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand |
| title_fullStr | An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand |
| title_full_unstemmed | An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand |
| title_short | An empirical evaluation of the SF-12, SF-6D,EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand |
| title_sort | empirical evaluation of the sf 12 sf 6d eq 5d and michigan hand outcome questionnaire in patients with rheumatoid arthritis of the hand |
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