Potent antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) inhibitors with improved drug-like properties

Potent antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) inhibitors with improved drug-like properties

A series of 2-pyrazolyl quinolones has been designed and synthesized in 5-7 steps to optimize for both in vitro antimalarial potency and various in vitro drug metabolism and pharmacokinetics (DMPK) features. The most potent compounds display no cross-resistance with multidrug resistant parasite stra...

书目详细资料
Main Authors:	Hong, W, Leung, SC, Amporndanai, K, Davies, J, Priestley, RS, Nixon, GL, Berry, NG, Hasnain, S, Antonyuk, S, Ward, SA, Biagini, GA, O'Neill, PM
格式:	Journal article
语言:	English
出版:	American Chemical Society 2018

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