Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide repeat (TPR) domains present in the ER lumen. AspH catalyses hydroxylation of asparaginyl- and aspartyl-residues in epidermal growth factor-like domains (EGFDs). Here we...

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Bibliographic Details
Main Authors:	Pfeffer, I, Brewitz, L, Krojer, T, Jensen, SA, Kochan, GT, Kershaw, NJ, Hewitson, KS, McNeill, LA, Kramer, H, Münzel, M, Hopkinson, RJ, Oppermann, U, Handford, PA, McDonough, MA, Schofield, CJ
Format:	Journal article
Language:	English
Published:	Nature Research 2019

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