T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2.
T3-associated disulphide linked heterodimers (Tin) comprised of clonally unique alpha-chains of molecular weight (MW) 49,000-54,000 and beta chains of MW 43,000 have been identified as the antigen receptors on human cytotoxic effector and inducer T-lymphocytes. Crosslinking of Ti molecules by either...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1984
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| _version_ | 1797052535467409408 |
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| author | Bensussan, A Acuto, O Hussey, R Milanese, C Reinherz, E |
| author_facet | Bensussan, A Acuto, O Hussey, R Milanese, C Reinherz, E |
| author_sort | Bensussan, A |
| collection | OXFORD |
| description | T3-associated disulphide linked heterodimers (Tin) comprised of clonally unique alpha-chains of molecular weight (MW) 49,000-54,000 and beta chains of MW 43,000 have been identified as the antigen receptors on human cytotoxic effector and inducer T-lymphocytes. Crosslinking of Ti molecules by either the appropriate nominal antigen/MHC specificity or anti-clonotypic monoclonal antibody results in clonal expansion of such cells via induction of IL-2 receptor expression, endogenous IL-2 release and IL-2-IL-2 receptor interaction. To determine whether analogous antigen receptor molecules and autocrine growth mechanisms are utilized by suppressor T-cells, we produced an anti-clonotypic monoclonal antibody against a non-cytotoxic T8+ suppressor T-cell, T8AC6, which defines a T3-associated disulphide-linked heterodimer of similar molecular weight to the above clonotypes. We find that Te-Ti triggering of suppressor clones (T8AC6, T8AC7 or T8RW) does not result in IL-2 production or T-cell proliferation and in contrast to inducer clones, also leads to a transient IL-2 unresponsive state. We suggest that such T3-Ti receptor mediated autoregulation of suppressor T-cell growth is necessary in the facilitation of initial inducer T-cell activation following antigenic perturbation. |
| first_indexed | 2024-03-06T18:32:57Z |
| format | Journal article |
| id | oxford-uuid:0a43832c-9877-4771-8fe5-c94a5e086766 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:32:57Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:0a43832c-9877-4771-8fe5-c94a5e0867662022-03-26T09:22:58ZT3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0a43832c-9877-4771-8fe5-c94a5e086766EnglishSymplectic Elements at Oxford1984Bensussan, AAcuto, OHussey, RMilanese, CReinherz, ET3-associated disulphide linked heterodimers (Tin) comprised of clonally unique alpha-chains of molecular weight (MW) 49,000-54,000 and beta chains of MW 43,000 have been identified as the antigen receptors on human cytotoxic effector and inducer T-lymphocytes. Crosslinking of Ti molecules by either the appropriate nominal antigen/MHC specificity or anti-clonotypic monoclonal antibody results in clonal expansion of such cells via induction of IL-2 receptor expression, endogenous IL-2 release and IL-2-IL-2 receptor interaction. To determine whether analogous antigen receptor molecules and autocrine growth mechanisms are utilized by suppressor T-cells, we produced an anti-clonotypic monoclonal antibody against a non-cytotoxic T8+ suppressor T-cell, T8AC6, which defines a T3-associated disulphide-linked heterodimer of similar molecular weight to the above clonotypes. We find that Te-Ti triggering of suppressor clones (T8AC6, T8AC7 or T8RW) does not result in IL-2 production or T-cell proliferation and in contrast to inducer clones, also leads to a transient IL-2 unresponsive state. We suggest that such T3-Ti receptor mediated autoregulation of suppressor T-cell growth is necessary in the facilitation of initial inducer T-cell activation following antigenic perturbation. |
| spellingShingle | Bensussan, A Acuto, O Hussey, R Milanese, C Reinherz, E T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. |
| title | T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. |
| title_full | T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. |
| title_fullStr | T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. |
| title_full_unstemmed | T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. |
| title_short | T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. |
| title_sort | t3 ti receptor triggering of t8 suppressor t cells leads to unresponsiveness to interleukin 2 |
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