Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction.
The decarboxylation of L-aspartate by E. coli L-aspartate-alpha-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1826258383111454720 |
|---|---|
| author | Saldanha, SA Birch, L Webb, M Nabbs, B von Delft, F Smith, A Abell, C |
| author_facet | Saldanha, SA Birch, L Webb, M Nabbs, B von Delft, F Smith, A Abell, C |
| author_sort | Saldanha, SA |
| collection | OXFORD |
| description | The decarboxylation of L-aspartate by E. coli L-aspartate-alpha-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism. |
| first_indexed | 2024-03-06T18:33:08Z |
| format | Journal article |
| id | oxford-uuid:0a55b82b-d5bc-4daa-861d-a2e315949613 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:33:08Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:0a55b82b-d5bc-4daa-861d-a2e3159496132022-03-26T09:23:16ZIdentification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0a55b82b-d5bc-4daa-861d-a2e315949613EnglishSymplectic Elements at Oxford2001Saldanha, SABirch, LWebb, MNabbs, Bvon Delft, FSmith, AAbell, CThe decarboxylation of L-aspartate by E. coli L-aspartate-alpha-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism. |
| spellingShingle | Saldanha, SA Birch, L Webb, M Nabbs, B von Delft, F Smith, A Abell, C Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
| title | Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
| title_full | Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
| title_fullStr | Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
| title_full_unstemmed | Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
| title_short | Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
| title_sort | identification of tyr58 as the proton donor in the aspartate alpha decarboxylase reaction |
| work_keys_str_mv | AT saldanhasa identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction AT birchl identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction AT webbm identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction AT nabbsb identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction AT vondelftf identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction AT smitha identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction AT abellc identificationoftyr58astheprotondonorintheaspartatealphadecarboxylasereaction |