Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction.
The decarboxylation of L-aspartate by E. coli L-aspartate-alpha-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism.
Main Authors: | Saldanha, SA, Birch, L, Webb, M, Nabbs, B, von Delft, F, Smith, A, Abell, C |
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Format: | Journal article |
Language: | English |
Published: |
2001
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