Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs988...
| প্রধান লেখক: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
2010
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| _version_ | 1826258461420158976 |
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| author | Freathy, R Mook-Kanamori, DO Sovio, U Prokopenko, I Timpson, N Berry, D Warrington, N Widen, E Hottenga, J Kaakinen, M Lange, L Bradfield, J Kerkhof, M Marsh, J Mägi, R Chen, C Lyon, H Kirin, M Adair, L Aulchenko, Y Bennett, A Borja, J Bouatia-Naji, N Charoen, P Coin, L |
| author_facet | Freathy, R Mook-Kanamori, DO Sovio, U Prokopenko, I Timpson, N Berry, D Warrington, N Widen, E Hottenga, J Kaakinen, M Lange, L Bradfield, J Kerkhof, M Marsh, J Mägi, R Chen, C Lyon, H Kirin, M Adair, L Aulchenko, Y Bennett, A Borja, J Bouatia-Naji, N Charoen, P Coin, L |
| author_sort | Freathy, R |
| collection | OXFORD |
| description | To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. |
| first_indexed | 2024-03-06T18:34:21Z |
| format | Journal article |
| id | oxford-uuid:0aba3430-b5d4-48cb-9617-e7aeb9c1b7da |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:34:21Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:0aba3430-b5d4-48cb-9617-e7aeb9c1b7da2022-03-26T09:25:22ZVariants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0aba3430-b5d4-48cb-9617-e7aeb9c1b7daEnglishSymplectic Elements at Oxford2010Freathy, RMook-Kanamori, DOSovio, UProkopenko, ITimpson, NBerry, DWarrington, NWiden, EHottenga, JKaakinen, MLange, LBradfield, JKerkhof, MMarsh, JMägi, RChen, CLyon, HKirin, MAdair, LAulchenko, YBennett, ABorja, JBouatia-Naji, NCharoen, PCoin, LTo identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. |
| spellingShingle | Freathy, R Mook-Kanamori, DO Sovio, U Prokopenko, I Timpson, N Berry, D Warrington, N Widen, E Hottenga, J Kaakinen, M Lange, L Bradfield, J Kerkhof, M Marsh, J Mägi, R Chen, C Lyon, H Kirin, M Adair, L Aulchenko, Y Bennett, A Borja, J Bouatia-Naji, N Charoen, P Coin, L Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. |
| title | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. |
| title_full | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. |
| title_fullStr | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. |
| title_full_unstemmed | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. |
| title_short | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. |
| title_sort | variants in adcy5 and near ccnl1 are associated with fetal growth and birth weight |
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