T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE)
Purpose: To optimize intracranial vessel wall imaging (VWI) at 7T for sharp wall depiction and high boundary contrast. <br/><br/>Methods: A variable flip angle turbo spin echo scheme (SPACE) was optimised for VWI. SPACE provides black-blood contrast, but has less crushing effect on CSF....
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| Format: | Journal article |
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Wiley
2016
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| _version_ | 1826258497128366080 |
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| author | Viessmann, O Li, L Benjamin, P Jezzard, P |
| author_facet | Viessmann, O Li, L Benjamin, P Jezzard, P |
| author_sort | Viessmann, O |
| collection | OXFORD |
| description | Purpose: To optimize intracranial vessel wall imaging (VWI) at 7T for sharp wall depiction and high boundary contrast. <br/><br/>Methods: A variable flip angle turbo spin echo scheme (SPACE) was optimised for VWI. SPACE provides black-blood contrast, but has less crushing effect on CSF. However, a delay alternating with nutation for tailored excitation (DANTE) preparation suppresses signal from slowly moving spins of a few mm/s. We therefore optimised a DANTE-preparation module for 7T. SNR, CNR and signal ratio for vessel wall, CSF and lumen were calculated for SPACE and DANTE-SPACE in 11 volunteers at the middle cerebral artery (MCA). An exemplar MCA stenosis patient was scanned with DANTE-SPACE. <br/><br/>Results: The 7T-optimised SPACE sequence improved vessel wall point-spread-function by 17%. The CNR between wall and CSF was doubled (12.2 versus 5.6) for the DANTE-SPACE scans compared to non-prepared SPACE. This increase was significant in the right hemisphere (p=0.016), but not in the left (p=0.090). CNR between wall and lumen halved, but remained at a high value (24.9 versus 56.5). <br/><br/>Conclusion: The optimised SPACE sequence improves VWI at 7T. Additional DANTE preparation increases contrast between wall and CSF. Increased outer boundary contrast comes at the cost of reduced inner boundary contrast. |
| first_indexed | 2024-03-06T18:34:54Z |
| format | Journal article |
| id | oxford-uuid:0ae2fc6b-9534-4abf-8cca-be9961c51f5e |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:34:54Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:0ae2fc6b-9534-4abf-8cca-be9961c51f5e2022-03-26T09:26:29ZT2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0ae2fc6b-9534-4abf-8cca-be9961c51f5eSymplectic Elements at OxfordWiley2016Viessmann, OLi, LBenjamin, PJezzard, PPurpose: To optimize intracranial vessel wall imaging (VWI) at 7T for sharp wall depiction and high boundary contrast. <br/><br/>Methods: A variable flip angle turbo spin echo scheme (SPACE) was optimised for VWI. SPACE provides black-blood contrast, but has less crushing effect on CSF. However, a delay alternating with nutation for tailored excitation (DANTE) preparation suppresses signal from slowly moving spins of a few mm/s. We therefore optimised a DANTE-preparation module for 7T. SNR, CNR and signal ratio for vessel wall, CSF and lumen were calculated for SPACE and DANTE-SPACE in 11 volunteers at the middle cerebral artery (MCA). An exemplar MCA stenosis patient was scanned with DANTE-SPACE. <br/><br/>Results: The 7T-optimised SPACE sequence improved vessel wall point-spread-function by 17%. The CNR between wall and CSF was doubled (12.2 versus 5.6) for the DANTE-SPACE scans compared to non-prepared SPACE. This increase was significant in the right hemisphere (p=0.016), but not in the left (p=0.090). CNR between wall and lumen halved, but remained at a high value (24.9 versus 56.5). <br/><br/>Conclusion: The optimised SPACE sequence improves VWI at 7T. Additional DANTE preparation increases contrast between wall and CSF. Increased outer boundary contrast comes at the cost of reduced inner boundary contrast. |
| spellingShingle | Viessmann, O Li, L Benjamin, P Jezzard, P T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE) |
| title | T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE) |
| title_full | T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE) |
| title_fullStr | T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE) |
| title_full_unstemmed | T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE) |
| title_short | T2-weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE) |
| title_sort | t2 weighted intracranial vessel wall imaging at 7 tesla using a dante prepared variable flip angle turbo spin echo readout dante space |
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