Visible light-mediated cyclizations of cyclic enones
<p>The work outlined in this thesis covers the development of visible light-mediated cyclizations of cyclic enones. Chapter one provides an overview of photochemical cyclizations, focusing on visible light-mediated cyclizations using triplet energy transfer from a suitable sensitizer, as well...
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| Format: | Thesis |
| Language: | English |
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2020
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| _version_ | 1826315574256336896 |
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| author | Parker, NA |
| author2 | Smith, M |
| author_facet | Smith, M Parker, NA |
| author_sort | Parker, NA |
| collection | OXFORD |
| description | <p>The work outlined in this thesis covers the development of visible light-mediated
cyclizations of cyclic enones. Chapter one provides an overview of photochemical
cyclizations, focusing on visible light-mediated cyclizations using triplet energy transfer
from a suitable sensitizer, as well as an overview of the photochemical cyclizations of cyclic
enones. Chapter two discusses the development of a visible light-mediated intramolecular
arylation of cyclic 2-arylheteroenones to generate a wide range of cis-fused heterocycles.</p>
<p>Chapter three details efforts into the photochemical synthesis of spirocyclic compounds via
intramolecular hydrogen atom abstraction using a cyclic enone chromophore. Chapter four
discusses the development of a visible light-mediated spirocyclization of cyclic
2-amidoenones. After initial optimization, the scope and scalability of the
reaction was explored, and derivatization of the products investigated. Subsequent
mechanistic experiments provided insight into the high diastereoselectivity of the reaction.</p>
<p>Chapter five looks at applications of the previously developed reactions to acyclic
chromophore systems, and the challenges present in this modification </p> |
| first_indexed | 2024-03-07T07:35:52Z |
| format | Thesis |
| id | oxford-uuid:0af487c1-fdd0-4292-890d-61f6a05c2149 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:28:44Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | oxford-uuid:0af487c1-fdd0-4292-890d-61f6a05c21492024-12-01T11:28:30ZVisible light-mediated cyclizations of cyclic enonesThesishttp://purl.org/coar/resource_type/c_db06uuid:0af487c1-fdd0-4292-890d-61f6a05c2149Organic ChemistryPhotochemistryEnglishORA Deposit2020Parker, NASmith, M<p>The work outlined in this thesis covers the development of visible light-mediated cyclizations of cyclic enones. Chapter one provides an overview of photochemical cyclizations, focusing on visible light-mediated cyclizations using triplet energy transfer from a suitable sensitizer, as well as an overview of the photochemical cyclizations of cyclic enones. Chapter two discusses the development of a visible light-mediated intramolecular arylation of cyclic 2-arylheteroenones to generate a wide range of cis-fused heterocycles.</p> <p>Chapter three details efforts into the photochemical synthesis of spirocyclic compounds via intramolecular hydrogen atom abstraction using a cyclic enone chromophore. Chapter four discusses the development of a visible light-mediated spirocyclization of cyclic 2-amidoenones. After initial optimization, the scope and scalability of the reaction was explored, and derivatization of the products investigated. Subsequent mechanistic experiments provided insight into the high diastereoselectivity of the reaction.</p> <p>Chapter five looks at applications of the previously developed reactions to acyclic chromophore systems, and the challenges present in this modification </p> |
| spellingShingle | Organic Chemistry Photochemistry Parker, NA Visible light-mediated cyclizations of cyclic enones |
| title | Visible light-mediated cyclizations of cyclic enones |
| title_full | Visible light-mediated cyclizations of cyclic enones |
| title_fullStr | Visible light-mediated cyclizations of cyclic enones |
| title_full_unstemmed | Visible light-mediated cyclizations of cyclic enones |
| title_short | Visible light-mediated cyclizations of cyclic enones |
| title_sort | visible light mediated cyclizations of cyclic enones |
| topic | Organic Chemistry Photochemistry |
| work_keys_str_mv | AT parkerna visiblelightmediatedcyclizationsofcyclicenones |