Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.
The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-bindin...
| मुख्य लेखकों: | , , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2007
|
| _version_ | 1826258526827184128 |
|---|---|
| author | Garín, M Chu, C Golshayan, D Cernuda-Morollón, E Wait, R Lechler, R |
| author_facet | Garín, M Chu, C Golshayan, D Cernuda-Morollón, E Wait, R Lechler, R |
| author_sort | Garín, M |
| collection | OXFORD |
| description | The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1-homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells. |
| first_indexed | 2024-03-06T18:35:21Z |
| format | Journal article |
| id | oxford-uuid:0b08dfd4-8946-44b4-baba-4d8d580b0d75 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:35:21Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:0b08dfd4-8946-44b4-baba-4d8d580b0d752022-03-26T09:27:18ZGalectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0b08dfd4-8946-44b4-baba-4d8d580b0d75EnglishSymplectic Elements at Oxford2007Garín, MChu, CGolshayan, DCernuda-Morollón, EWait, RLechler, RThe naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1-homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells. |
| spellingShingle | Garín, M Chu, C Golshayan, D Cernuda-Morollón, E Wait, R Lechler, R Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. |
| title | Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. |
| title_full | Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. |
| title_fullStr | Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. |
| title_full_unstemmed | Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. |
| title_short | Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. |
| title_sort | galectin 1 a key effector of regulation mediated by cd4 cd25 t cells |
| work_keys_str_mv | AT garinm galectin1akeyeffectorofregulationmediatedbycd4cd25tcells AT chuc galectin1akeyeffectorofregulationmediatedbycd4cd25tcells AT golshayand galectin1akeyeffectorofregulationmediatedbycd4cd25tcells AT cernudamorollone galectin1akeyeffectorofregulationmediatedbycd4cd25tcells AT waitr galectin1akeyeffectorofregulationmediatedbycd4cd25tcells AT lechlerr galectin1akeyeffectorofregulationmediatedbycd4cd25tcells |