A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool for monitoring AR in malaria endemic countries. Molecular Pfk13 surveillance r...

Bibliografiset tiedot
Päätekijät:	Ndwiga, L, Kimenyi, KM, Wamae, K, Osoti, V, Akinyi, M, Omedo, I, Ishengoma, DS, Duah-Quashie, N, Andagalu, B, Ghansah, A, Amambua-Ngwa, A, Tukwasibwe, S, Tessema, SK, Karema, C, Djimde, AA, Dondorp, AM, Raman, J, Snow, RW, Bejon, P, Ochola-Oyier, LI
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Australian Society for Parasitology 2021

Samankaltaisia teoksia

No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites
Tekijä: Wamae, K, et al.
Julkaistu: (2019)

Targeted amplicon deep sequencing for monitoring antimalarial resistance markers in western Kenya
Tekijä: Osoti, V, et al.
Julkaistu: (2022)

Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya
Tekijä: Osoti, V, et al.
Julkaistu: (2025)

Understanding P. falciparum asymptomatic infections: a proposition for a transcriptomic approach
Tekijä: Kimenyi, KM, et al.
Julkaistu: (2019)

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018
Tekijä: Kimenyi, KM, et al.
Julkaistu: (2022)

The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations
Tekijä: Ndwiga, L, et al.
Julkaistu: (2021)

Amplicon sequencing as a potential surveillance tool for complexity of infection and drug resistance markers in Plasmodium falciparum asymptomatic infections
Tekijä: Wamae, K, et al.
Julkaistu: (2022)

Fitness costs and the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance
Tekijä: Nair, S, et al.
Julkaistu: (2018)

Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook
Tekijä: Ghansah, A, et al.
Julkaistu: (2019)

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea
Tekijä: Miotto, O, et al.
Julkaistu: (2020)

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea
Tekijä: Miotto, O, et al.
Julkaistu: (2019)

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia : in vivo therapeutic efficacy and kelch13 molecular marker surveillance
Tekijä: Grigg, Matthew J., et al.
Julkaistu: (2019)

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance
Tekijä: Grigg, M, et al.
Julkaistu: (2018)

Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection
Tekijä: Ochola-Oyier, L, et al.
Julkaistu: (2019)

Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)
Tekijä: Raman, J, et al.
Julkaistu: (2019)

Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected
Tekijä: Kimenyi, KM, et al.
Julkaistu: (2024)

Monitoring parasite diversity for malaria elimination in sub-Saharan Africa.
Tekijä: Ghansah, A, et al.
Julkaistu: (2014)

Major subpopulations of Plasmodium falciparum in sub-Saharan Africa
Tekijä: Amambua-Ngwa, A, et al.
Julkaistu: (2019)

Optimisation of purification of plasmodium falciparum Kelch13 protein for structural analysis
Tekijä: Seo, Gilia Min Li
Julkaistu: (2023)

Understanding substrate recruitment by BTB-Kelch family E3 ligases
Tekijä: Chen, Z
Julkaistu: (2019)

Application of loop-mediated isothermal amplification combined with lateral flow assay visualization of Plasmodium falciparum kelch 13 C580Y mutation for artemisinin resistance detection in clinical samples
Tekijä: Sanmoung, W, et al.
Julkaistu: (2023)

Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study
Tekijä: Apinjoh, T, et al.
Julkaistu: (2017)

Transmission and age impact the risk of developing febrile malaria in children with asymptomatic Plasmodium falciparum parasitemia
Tekijä: Wamae, K, et al.
Julkaistu: (2018)

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
Tekijä: Ashley, E, et al.
Julkaistu: (2019)

Detection of mutated Plasmodium vivax Kelch propeller domain (PvK12) in Malaysian isolates
Tekijä: Shairah, Dzul, et al.
Julkaistu: (2018)

Limited polymorphism of the Kelch propeller domain in P. malariae and P. ovale isolates from Thailand.
Tekijä: Nakeesathit, S, et al.
Julkaistu: (2016)

Limited polymorphism of the Kelch propeller domain in Plasmodium malariae and P. ovale isolates from Thailand.
Tekijä: Nakeesathit, S, et al.
Julkaistu: (2016)

Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa
Tekijä: Omedo, I, et al.
Julkaistu: (2017)

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Tekijä: Canning, P, et al.
Julkaistu: (2013)

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Tekijä: Canning, P, et al.
Julkaistu: (2013)

Prospective identification of malaria parasite genes under balancing selection.
Tekijä: Tetteh, K, et al.
Julkaistu: (2009)

Triple artemisinin-based combination therapies for malaria – a new paradigm?
Tekijä: van der Pluijm, RW, et al.
Julkaistu: (2020)

Artemisinin: current status.
Tekijä: White, N
Julkaistu: (1994)

Intrarectal artemisinin derivatives.
Tekijä: Nosten, F, et al.
Julkaistu: (1998)

Artemisinin-based combinations.
Tekijä: Ashley, E, et al.
Julkaistu: (2005)

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.
Tekijä: Guttery, D, et al.
Julkaistu: (2012)

The design and evaluation of a mobile system for rapid diagnostic test interpretation
Tekijä: Park, C, et al.
Julkaistu: (2021)

Is triple artemisinin-based combination therapy necessary for uncomplicated malaria?
Tekijä: van der Pluijm, RW, et al.
Julkaistu: (2022)

Plasmodium falciparum Kelch 13 mutations and treatment response in patients in Hpa-Pun District, Northern Kayin State, Myanmar.
Tekijä: Bonnington, C, et al.
Julkaistu: (2017)

Artemisinin-resistant malaria in Africa demands urgent action
Tekijä: Dhorda, M, et al.
Julkaistu: (2024)