Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India
Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.6...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Association for the Advancement of Science
2021
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| _version_ | 1826312827456978944 |
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| author | Dhar, MS Marwal, R Vs, R Ponnusamy, K Jolly, B Bhoyar, RC Sardana, V Naushin, S Rophina, M Mellan, TA Mishra, S Whittaker, C Fatihi, S Datta, M Singh, P Sharma, U Ujjainiya, R Bhatheja, N Divakar, MK Singh, MK Imran, M Senthivel, V Maurya, R Jha, N Mehta, P A, V Sharma, P Vr, A Chaudhary, U Soni, N Thukral, L Flaxman, S Bhatt, S Pandey, R Dash, D Faruq, M Lall, H Gogia, H Madan, P Kulkarni, S Chauhan, H Sengupta, S Kabra, S Indian SARS-CoV-2 Genomics Consortium (INSACOG)‡ Gupta, RK Singh, SK Agrawal, A Rakshit, P |
| author_facet | Dhar, MS Marwal, R Vs, R Ponnusamy, K Jolly, B Bhoyar, RC Sardana, V Naushin, S Rophina, M Mellan, TA Mishra, S Whittaker, C Fatihi, S Datta, M Singh, P Sharma, U Ujjainiya, R Bhatheja, N Divakar, MK Singh, MK Imran, M Senthivel, V Maurya, R Jha, N Mehta, P A, V Sharma, P Vr, A Chaudhary, U Soni, N Thukral, L Flaxman, S Bhatt, S Pandey, R Dash, D Faruq, M Lall, H Gogia, H Madan, P Kulkarni, S Chauhan, H Sengupta, S Kabra, S Indian SARS-CoV-2 Genomics Consortium (INSACOG)‡ Gupta, RK Singh, SK Agrawal, A Rakshit, P |
| author_sort | Dhar, MS |
| collection | OXFORD |
| description | Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi. |
| first_indexed | 2024-04-09T03:57:19Z |
| format | Journal article |
| id | oxford-uuid:0b1cce9e-8f38-4838-a392-3cae62fa9cb4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:01:11Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:0b1cce9e-8f38-4838-a392-3cae62fa9cb42024-04-30T16:07:08ZGenomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, IndiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0b1cce9e-8f38-4838-a392-3cae62fa9cb4EnglishSymplectic ElementsAmerican Association for the Advancement of Science2021Dhar, MSMarwal, RVs, RPonnusamy, KJolly, BBhoyar, RCSardana, VNaushin, SRophina, MMellan, TAMishra, SWhittaker, CFatihi, SDatta, MSingh, PSharma, UUjjainiya, RBhatheja, NDivakar, MKSingh, MKImran, MSenthivel, VMaurya, RJha, NMehta, PA, VSharma, PVr, AChaudhary, USoni, NThukral, LFlaxman, SBhatt, SPandey, RDash, DFaruq, MLall, HGogia, HMadan, PKulkarni, SChauhan, HSengupta, SKabra, SIndian SARS-CoV-2 Genomics Consortium (INSACOG)‡Gupta, RKSingh, SKAgrawal, ARakshit, PDelhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi. |
| spellingShingle | Dhar, MS Marwal, R Vs, R Ponnusamy, K Jolly, B Bhoyar, RC Sardana, V Naushin, S Rophina, M Mellan, TA Mishra, S Whittaker, C Fatihi, S Datta, M Singh, P Sharma, U Ujjainiya, R Bhatheja, N Divakar, MK Singh, MK Imran, M Senthivel, V Maurya, R Jha, N Mehta, P A, V Sharma, P Vr, A Chaudhary, U Soni, N Thukral, L Flaxman, S Bhatt, S Pandey, R Dash, D Faruq, M Lall, H Gogia, H Madan, P Kulkarni, S Chauhan, H Sengupta, S Kabra, S Indian SARS-CoV-2 Genomics Consortium (INSACOG)‡ Gupta, RK Singh, SK Agrawal, A Rakshit, P Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India |
| title | Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India |
| title_full | Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India |
| title_fullStr | Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India |
| title_full_unstemmed | Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India |
| title_short | Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India |
| title_sort | genomic characterization and epidemiology of an emerging sars cov 2 variant in delhi india |
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