Subsequent event risk in individuals with established coronary heart disease
<p><strong>Background</strong> The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.</p> <p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Heart Association
2019
|
| _version_ | 1826258579600965632 |
|---|---|
| author | Patel, R Tragante, V Schmidt, AF McCubrey, RO Holmes, MV Howe, LJ Direk, K Åkerblom, A Leander, K Virani, SS Kaminski, KA Muehlschlegel, JD Allayee, H Almgren, P Alver, M Baranova, EV Behlouli, H Boeckx, B Braund, PS Breitling, LP Delgado, G Duarte, NE Dubé, M-P Dufresne, L Eriksson, N Foco, L Scholz, M Gijsberts, CM Glinge, C Gong, Y Hartiala, J Heydarpour, M Hubacek, JA Kleber, M Kofink, D Kotti, S Kuukasjärvi, P Lee, V-V Leiherer, A Lenzini, PA Levin, D Lyytikäinen, L-P Martinelli, N Mons, U Nelson, CP Nikus, K Pilbrow, AP Ploski, R Sun, YV Tanck, MWT Tang, WHW Trompet, S Van Der Laan, SW Van Setten, J Vilmundarson, RO Anselmi, C Vlachopoulou, E Ali, L Boerwinkle, E Briguori, C Carlquist, JF Carruthers, KF Casu, G Deanfield, J Deloukas, P Dudbridge, F Engström, T Fitzpatrick, N Fox, K Gigante, B James, S Lokki, M-L Lotufo, PA Marziliano, N Mordi, IR Muhlestein, JB Newton-Cheh, C Pitha, J Saely, CH Samman-Tahhan, A Sandesara, PB Teren, A Timmis, A Van De Werf, F Wauters, E Wilde, AAM Ford, I Stott, DJ Algra, A Andreassi, MG Ardissino, D Arsenault, BJ Ballantyne, CM Bergmeijer, TO Bezzina, CR Body, SC Boersma, EH Bogaty, P Bots, M Brenner, H Brugts, JJ Burkhardt, R Carpeggiani, C Condorelli, G Cooper-Dehoff, RM Cresci, S Danchin, N De Faire, U Doughty, RN Drexel, H Engert, JC Fox, KAA Girelli, D Grobbee, DE Hagström, E Hazen, SL Held, C Hemingway, H Hoefer, IE Hovingh, GK Jabbari, R Johnson, JA Jukema, JW Kaczor, MP Kähönen, M Kettner, J Kiliszek, M Klungel, OH Lagerqvist, B Lambrechts, D Laurikka, JO Lehtimäki, T Lindholm, D Mahmoodi, BK Der Zee, AH McPherson, R Melander, O Metspalu, A Niemcunowicz-Janica, A Olivieri, O Opolski, G Palmer, CN Pasterkamp, G Pepine, CJ Pereira, AC Pilote, L Quyyumi, AA Richards, AM Sanak, M Siegbahn, A Simon, T Sinisalo, J Smith, JG Spertus, JA Stender, S Stewart, AFR Szczeklik, W Szpakowicz, A Tardif, J-C Berg, JM Tfelt-Hansen, J Thanassoulis, G Thiery, J Torp-Pedersen, C Van Der Graaf, Y Visseren, FLJ Waltenberger, J Weeke, PE Van Der Harst, P Lang, CC Sattar, N Cameron, VA Anderson, JL Brophy, JM Paré, G Horne, BD März, W Wallentin, L Samani, NJ Hingorani, AD Asselbergs, FW |
| author_facet | Patel, R Tragante, V Schmidt, AF McCubrey, RO Holmes, MV Howe, LJ Direk, K Åkerblom, A Leander, K Virani, SS Kaminski, KA Muehlschlegel, JD Allayee, H Almgren, P Alver, M Baranova, EV Behlouli, H Boeckx, B Braund, PS Breitling, LP Delgado, G Duarte, NE Dubé, M-P Dufresne, L Eriksson, N Foco, L Scholz, M Gijsberts, CM Glinge, C Gong, Y Hartiala, J Heydarpour, M Hubacek, JA Kleber, M Kofink, D Kotti, S Kuukasjärvi, P Lee, V-V Leiherer, A Lenzini, PA Levin, D Lyytikäinen, L-P Martinelli, N Mons, U Nelson, CP Nikus, K Pilbrow, AP Ploski, R Sun, YV Tanck, MWT Tang, WHW Trompet, S Van Der Laan, SW Van Setten, J Vilmundarson, RO Anselmi, C Vlachopoulou, E Ali, L Boerwinkle, E Briguori, C Carlquist, JF Carruthers, KF Casu, G Deanfield, J Deloukas, P Dudbridge, F Engström, T Fitzpatrick, N Fox, K Gigante, B James, S Lokki, M-L Lotufo, PA Marziliano, N Mordi, IR Muhlestein, JB Newton-Cheh, C Pitha, J Saely, CH Samman-Tahhan, A Sandesara, PB Teren, A Timmis, A Van De Werf, F Wauters, E Wilde, AAM Ford, I Stott, DJ Algra, A Andreassi, MG Ardissino, D Arsenault, BJ Ballantyne, CM Bergmeijer, TO Bezzina, CR Body, SC Boersma, EH Bogaty, P Bots, M Brenner, H Brugts, JJ Burkhardt, R Carpeggiani, C Condorelli, G Cooper-Dehoff, RM Cresci, S Danchin, N De Faire, U Doughty, RN Drexel, H Engert, JC Fox, KAA Girelli, D Grobbee, DE Hagström, E Hazen, SL Held, C Hemingway, H Hoefer, IE Hovingh, GK Jabbari, R Johnson, JA Jukema, JW Kaczor, MP Kähönen, M Kettner, J Kiliszek, M Klungel, OH Lagerqvist, B Lambrechts, D Laurikka, JO Lehtimäki, T Lindholm, D Mahmoodi, BK Der Zee, AH McPherson, R Melander, O Metspalu, A Niemcunowicz-Janica, A Olivieri, O Opolski, G Palmer, CN Pasterkamp, G Pepine, CJ Pereira, AC Pilote, L Quyyumi, AA Richards, AM Sanak, M Siegbahn, A Simon, T Sinisalo, J Smith, JG Spertus, JA Stender, S Stewart, AFR Szczeklik, W Szpakowicz, A Tardif, J-C Berg, JM Tfelt-Hansen, J Thanassoulis, G Thiery, J Torp-Pedersen, C Van Der Graaf, Y Visseren, FLJ Waltenberger, J Weeke, PE Van Der Harst, P Lang, CC Sattar, N Cameron, VA Anderson, JL Brophy, JM Paré, G Horne, BD März, W Wallentin, L Samani, NJ Hingorani, AD Asselbergs, FW |
| author_sort | Patel, R |
| collection | OXFORD |
| description | <p><strong>Background</strong> The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.</p> <p><strong>Methods</strong> The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.</p> <p><strong>Results</strong> Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%–100%), mostly male (44%–91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14–1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13–1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35–1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.</p> <p><strong>Conclusions</strong> GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.</p> |
| first_indexed | 2024-03-06T18:36:19Z |
| format | Journal article |
| id | oxford-uuid:0b50d019-93ba-42dd-aa46-b8d7be6c3058 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:36:19Z |
| publishDate | 2019 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:0b50d019-93ba-42dd-aa46-b8d7be6c30582022-03-26T09:29:00ZSubsequent event risk in individuals with established coronary heart diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0b50d019-93ba-42dd-aa46-b8d7be6c3058EnglishSymplectic Elements at OxfordAmerican Heart Association2019Patel, RTragante, VSchmidt, AFMcCubrey, ROHolmes, MVHowe, LJDirek, KÅkerblom, ALeander, KVirani, SSKaminski, KAMuehlschlegel, JDAllayee, HAlmgren, PAlver, MBaranova, EVBehlouli, HBoeckx, BBraund, PSBreitling, LPDelgado, GDuarte, NEDubé, M-PDufresne, LEriksson, NFoco, LScholz, MGijsberts, CMGlinge, CGong, YHartiala, JHeydarpour, MHubacek, JAKleber, MKofink, DKotti, SKuukasjärvi, PLee, V-VLeiherer, ALenzini, PALevin, DLyytikäinen, L-PMartinelli, NMons, UNelson, CPNikus, KPilbrow, APPloski, RSun, YVTanck, MWTTang, WHWTrompet, SVan Der Laan, SWVan Setten, JVilmundarson, ROAnselmi, CVlachopoulou, EAli, LBoerwinkle, EBriguori, CCarlquist, JFCarruthers, KFCasu, GDeanfield, JDeloukas, PDudbridge, FEngström, TFitzpatrick, NFox, KGigante, BJames, SLokki, M-LLotufo, PAMarziliano, NMordi, IRMuhlestein, JBNewton-Cheh, CPitha, JSaely, CHSamman-Tahhan, ASandesara, PBTeren, ATimmis, AVan De Werf, FWauters, EWilde, AAMFord, IStott, DJAlgra, AAndreassi, MGArdissino, DArsenault, BJBallantyne, CMBergmeijer, TOBezzina, CRBody, SCBoersma, EHBogaty, PBots, MBrenner, HBrugts, JJBurkhardt, RCarpeggiani, CCondorelli, GCooper-Dehoff, RMCresci, SDanchin, NDe Faire, UDoughty, RNDrexel, HEngert, JCFox, KAAGirelli, DGrobbee, DEHagström, EHazen, SLHeld, CHemingway, HHoefer, IEHovingh, GKJabbari, RJohnson, JAJukema, JWKaczor, MPKähönen, MKettner, JKiliszek, MKlungel, OHLagerqvist, BLambrechts, DLaurikka, JOLehtimäki, TLindholm, DMahmoodi, BKDer Zee, AHMcPherson, RMelander, OMetspalu, ANiemcunowicz-Janica, AOlivieri, OOpolski, GPalmer, CNPasterkamp, GPepine, CJPereira, ACPilote, LQuyyumi, AARichards, AMSanak, MSiegbahn, ASimon, TSinisalo, JSmith, JGSpertus, JAStender, SStewart, AFRSzczeklik, WSzpakowicz, ATardif, J-CBerg, JMTfelt-Hansen, JThanassoulis, GThiery, JTorp-Pedersen, CVan Der Graaf, YVisseren, FLJWaltenberger, JWeeke, PEVan Der Harst, PLang, CCSattar, NCameron, VAAnderson, JLBrophy, JMParé, GHorne, BDMärz, WWallentin, LSamani, NJHingorani, ADAsselbergs, FW<p><strong>Background</strong> The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.</p> <p><strong>Methods</strong> The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.</p> <p><strong>Results</strong> Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%–100%), mostly male (44%–91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14–1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13–1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35–1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.</p> <p><strong>Conclusions</strong> GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.</p> |
| spellingShingle | Patel, R Tragante, V Schmidt, AF McCubrey, RO Holmes, MV Howe, LJ Direk, K Åkerblom, A Leander, K Virani, SS Kaminski, KA Muehlschlegel, JD Allayee, H Almgren, P Alver, M Baranova, EV Behlouli, H Boeckx, B Braund, PS Breitling, LP Delgado, G Duarte, NE Dubé, M-P Dufresne, L Eriksson, N Foco, L Scholz, M Gijsberts, CM Glinge, C Gong, Y Hartiala, J Heydarpour, M Hubacek, JA Kleber, M Kofink, D Kotti, S Kuukasjärvi, P Lee, V-V Leiherer, A Lenzini, PA Levin, D Lyytikäinen, L-P Martinelli, N Mons, U Nelson, CP Nikus, K Pilbrow, AP Ploski, R Sun, YV Tanck, MWT Tang, WHW Trompet, S Van Der Laan, SW Van Setten, J Vilmundarson, RO Anselmi, C Vlachopoulou, E Ali, L Boerwinkle, E Briguori, C Carlquist, JF Carruthers, KF Casu, G Deanfield, J Deloukas, P Dudbridge, F Engström, T Fitzpatrick, N Fox, K Gigante, B James, S Lokki, M-L Lotufo, PA Marziliano, N Mordi, IR Muhlestein, JB Newton-Cheh, C Pitha, J Saely, CH Samman-Tahhan, A Sandesara, PB Teren, A Timmis, A Van De Werf, F Wauters, E Wilde, AAM Ford, I Stott, DJ Algra, A Andreassi, MG Ardissino, D Arsenault, BJ Ballantyne, CM Bergmeijer, TO Bezzina, CR Body, SC Boersma, EH Bogaty, P Bots, M Brenner, H Brugts, JJ Burkhardt, R Carpeggiani, C Condorelli, G Cooper-Dehoff, RM Cresci, S Danchin, N De Faire, U Doughty, RN Drexel, H Engert, JC Fox, KAA Girelli, D Grobbee, DE Hagström, E Hazen, SL Held, C Hemingway, H Hoefer, IE Hovingh, GK Jabbari, R Johnson, JA Jukema, JW Kaczor, MP Kähönen, M Kettner, J Kiliszek, M Klungel, OH Lagerqvist, B Lambrechts, D Laurikka, JO Lehtimäki, T Lindholm, D Mahmoodi, BK Der Zee, AH McPherson, R Melander, O Metspalu, A Niemcunowicz-Janica, A Olivieri, O Opolski, G Palmer, CN Pasterkamp, G Pepine, CJ Pereira, AC Pilote, L Quyyumi, AA Richards, AM Sanak, M Siegbahn, A Simon, T Sinisalo, J Smith, JG Spertus, JA Stender, S Stewart, AFR Szczeklik, W Szpakowicz, A Tardif, J-C Berg, JM Tfelt-Hansen, J Thanassoulis, G Thiery, J Torp-Pedersen, C Van Der Graaf, Y Visseren, FLJ Waltenberger, J Weeke, PE Van Der Harst, P Lang, CC Sattar, N Cameron, VA Anderson, JL Brophy, JM Paré, G Horne, BD März, W Wallentin, L Samani, NJ Hingorani, AD Asselbergs, FW Subsequent event risk in individuals with established coronary heart disease |
| title | Subsequent event risk in individuals with established coronary heart disease |
| title_full | Subsequent event risk in individuals with established coronary heart disease |
| title_fullStr | Subsequent event risk in individuals with established coronary heart disease |
| title_full_unstemmed | Subsequent event risk in individuals with established coronary heart disease |
| title_short | Subsequent event risk in individuals with established coronary heart disease |
| title_sort | subsequent event risk in individuals with established coronary heart disease |
| work_keys_str_mv | AT patelr subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT tragantev subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT schmidtaf subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT mccubreyro subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT holmesmv subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT howelj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT direkk subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT akerbloma subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT leanderk subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT viraniss subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kaminskika subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT muehlschlegeljd subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT allayeeh subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT almgrenp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT alverm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT baranovaev subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT behloulih subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT boeckxb subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT braundps subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT breitlinglp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT delgadog subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT duartene subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT dubemp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT dufresnel subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT erikssonn subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT focol subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT scholzm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT gijsbertscm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT glingec subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT gongy subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hartialaj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT heydarpourm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hubacekja subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kleberm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kofinkd subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kottis subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kuukasjarvip subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT leevv subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT leiherera subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lenzinipa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT levind subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lyytikainenlp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT martinellin subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT monsu subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT nelsoncp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT nikusk subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pilbrowap subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT ploskir subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT sunyv subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT tanckmwt subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT tangwhw subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT trompets subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vanderlaansw subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vansettenj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vilmundarsonro subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT anselmic subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vlachopouloue subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT alil subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT boerwinklee subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT briguoric subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT carlquistjf subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT carrutherskf subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT casug subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT deanfieldj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT deloukasp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT dudbridgef subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT engstromt subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT fitzpatrickn subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT foxk subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT giganteb subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT jamess subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lokkiml subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lotufopa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT marzilianon subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT mordiir subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT muhlesteinjb subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT newtonchehc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pithaj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT saelych subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT sammantahhana subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT sandesarapb subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT terena subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT timmisa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vandewerff subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT wauterse subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT wildeaam subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT fordi subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT stottdj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT algraa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT andreassimg subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT ardissinod subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT arsenaultbj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT ballantynecm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT bergmeijerto subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT bezzinacr subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT bodysc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT boersmaeh subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT bogatyp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT botsm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT brennerh subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT brugtsjj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT burkhardtr subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT carpeggianic subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT condorellig subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT cooperdehoffrm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT crescis subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT danchinn subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT defaireu subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT doughtyrn subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT drexelh subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT engertjc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT foxkaa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT girellid subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT grobbeede subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hagstrome subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hazensl subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT heldc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hemingwayh subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hoeferie subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hovinghgk subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT jabbarir subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT johnsonja subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT jukemajw subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kaczormp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kahonenm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kettnerj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT kiliszekm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT klungeloh subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lagerqvistb subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lambrechtsd subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT laurikkajo subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lehtimakit subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT lindholmd subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT mahmoodibk subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT derzeeah subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT mcphersonr subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT melandero subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT metspalua subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT niemcunowiczjanicaa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT olivierio subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT opolskig subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT palmercn subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pasterkampg subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pepinecj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pereiraac subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pilotel subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT quyyumiaa subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT richardsam subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT sanakm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT siegbahna subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT simont subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT sinisaloj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT smithjg subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT spertusja subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT stenders subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT stewartafr subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT szczeklikw subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT szpakowicza subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT tardifjc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT bergjm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT tfelthansenj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT thanassoulisg subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT thieryj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT torppedersenc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vandergraafy subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT visserenflj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT waltenbergerj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT weekepe subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT vanderharstp subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT langcc subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT sattarn subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT cameronva subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT andersonjl subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT brophyjm subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT pareg subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hornebd subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT marzw subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT wallentinl subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT samaninj subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT hingoraniad subsequenteventriskinindividualswithestablishedcoronaryheartdisease AT asselbergsfw subsequenteventriskinindividualswithestablishedcoronaryheartdisease |