Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bo...
Main Authors: | Johnston, M, Edwards, C, Bodmer, W, Maini, P, Chapman, S |
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Format: | Journal article |
Published: |
2007
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