Coordinated hedgehog signaling induces new hair follicles in adult skin
Hair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we reveal that activation of Hedgehog (Hh) signaling...
| Autores principales: | , , , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications
2020
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| _version_ | 1826258642710560768 |
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| author | Sun, X Are, A Annusver, K Sivan, U Jacob, T Dalessandri, T Joost, S Füllgrabe, A Gerling, M Kasper, M |
| author_facet | Sun, X Are, A Annusver, K Sivan, U Jacob, T Dalessandri, T Joost, S Füllgrabe, A Gerling, M Kasper, M |
| author_sort | Sun, X |
| collection | OXFORD |
| description | Hair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we reveal that activation of Hedgehog (Hh) signaling in adjacent epithelial and stromal cells induces new HFs in adult, unwounded dorsal mouse skin. Formation of de novo HFs recapitulated embryonic HF development, and mature follicles produced hair co-occurring with epithelial tumors. In contrast, Hh-pathway activation in epithelial or stromal cells alone resulted in tumor formation or stromal cell condensation respectively, without induction of new HFs. Provocatively, adjacent epithelial-stromal Hh-pathway activation induced de novo HFs also in hairless paw skin, divorced from confounding effects of pre-existing niche signals in haired skin. Altogether, cell-type-specific modulation of a single pathway is sufficient to reactivate embryonic programs in adult tissues, thereby inducing complex epithelial structures even without wounding. |
| first_indexed | 2024-03-06T18:37:10Z |
| format | Journal article |
| id | oxford-uuid:0ba2b1bc-780e-4938-8147-4a72a0f56933 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:37:10Z |
| publishDate | 2020 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:0ba2b1bc-780e-4938-8147-4a72a0f569332022-03-26T09:30:32ZCoordinated hedgehog signaling induces new hair follicles in adult skinJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0ba2b1bc-780e-4938-8147-4a72a0f56933EnglishSymplectic ElementseLife Sciences Publications2020Sun, XAre, AAnnusver, KSivan, UJacob, TDalessandri, TJoost, SFüllgrabe, AGerling, MKasper, MHair follicle (HF) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells. In humans this process only occurs during embryogenesis and viable strategies to induce new HFs in adult skin are lacking. Here, we reveal that activation of Hedgehog (Hh) signaling in adjacent epithelial and stromal cells induces new HFs in adult, unwounded dorsal mouse skin. Formation of de novo HFs recapitulated embryonic HF development, and mature follicles produced hair co-occurring with epithelial tumors. In contrast, Hh-pathway activation in epithelial or stromal cells alone resulted in tumor formation or stromal cell condensation respectively, without induction of new HFs. Provocatively, adjacent epithelial-stromal Hh-pathway activation induced de novo HFs also in hairless paw skin, divorced from confounding effects of pre-existing niche signals in haired skin. Altogether, cell-type-specific modulation of a single pathway is sufficient to reactivate embryonic programs in adult tissues, thereby inducing complex epithelial structures even without wounding. |
| spellingShingle | Sun, X Are, A Annusver, K Sivan, U Jacob, T Dalessandri, T Joost, S Füllgrabe, A Gerling, M Kasper, M Coordinated hedgehog signaling induces new hair follicles in adult skin |
| title | Coordinated hedgehog signaling induces new hair follicles in adult skin |
| title_full | Coordinated hedgehog signaling induces new hair follicles in adult skin |
| title_fullStr | Coordinated hedgehog signaling induces new hair follicles in adult skin |
| title_full_unstemmed | Coordinated hedgehog signaling induces new hair follicles in adult skin |
| title_short | Coordinated hedgehog signaling induces new hair follicles in adult skin |
| title_sort | coordinated hedgehog signaling induces new hair follicles in adult skin |
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