Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Background: Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult cortex and hippocampus in rodents, primates and humans, with adult NSC differentiation sharing key regulatory mech...

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Bibliographic Details
Main Authors: Charou, D, Rogdakis, T, Latorrata, A, Valcarcel, M, Papadogiannis, V, Athanasiou, C, Tsengenes, A, Papadopoulou, MA, Lypitkas, D, Lavigne, MD, Katsila, T, Wade, RC, Cader, MZ, Calogeropoulou, T, Gravanis, A, Charalampopoulos, I
Format: Journal article
Language:English
Published: BioMed Central 2024

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