Determinants of neuronal firing patterns in the hippocampus
<p>The activity of networks subserving memory and learning in the hippocampus is under the control of GABAergic interneurons. In order to test the contribution of distinct cell types, I have recorded extracellularly, labelled, and identified different types of interneuron in area CA3 of the hi...
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| Formato: | Thesis |
| Idioma: | English |
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2009
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| _version_ | 1826315590729465856 |
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| author | Tukker, JJ |
| author2 | Somogyi, P |
| author_facet | Somogyi, P Tukker, JJ |
| author_sort | Tukker, JJ |
| collection | OXFORD |
| description | <p>The activity of networks subserving memory and learning in the hippocampus is under the control of GABAergic interneurons. In order to test the contribution of distinct cell types, I have recorded extracellularly, labelled, and identified different types of interneuron in area CA3 of the hippocampus, a region implicated in the generation of gamma and theta oscillations, and the initiation of sharp-waves.</p> <p>I present here a detailed analysis of the spike timing of parvalbumin-positive (PV) basket and physiologically identified pyramidal cells in area CA3, relative to various network states recorded in area CA3 and CA1 simultaneously. Additionally, I have shown by detailed analysis that five classes of previously recorded and identified CA1 interneuron fired with cell type specific firing patterns relative to local gamma oscillations.</p> <p>In CA3, PV basket cells fired phase locked to theta and gamma oscillations recorded in CA1 as well as in CA3, and increased their firing rates during CA1 sharp-waves. Pyramidal cells in CA3 were also phase-locked, but fired at phases different from basket cells. During theta oscillations, CA3 pyramidal and PV basket cells were phase locked to both CA1 and CA3 theta equally, suggesting a wide coherence of these oscillations; in contrast, cells fired more strongly phase-locked to gamma oscillations in CA3 than in CA1, suggesting a specific role for CA3 in the generation of this rhythm. In contrast to theta and gamma oscillations, CA3 basket cells were phase-locked to ripples in area CA3 but not in CA1.</p> <p>Overall, my results show that the spike timing of several types of interneuron in CA1, and PV basket cells in CA3, is correlated in a cell- and area-specific manner with the generation of particular states of synchronous activity.</p> |
| first_indexed | 2024-03-06T18:38:18Z |
| format | Thesis |
| id | oxford-uuid:0c0c8f92-e146-4e2a-b7f3-6d27a9b12387 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:29:01Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:0c0c8f92-e146-4e2a-b7f3-6d27a9b123872024-12-01T11:46:11ZDeterminants of neuronal firing patterns in the hippocampusThesishttp://purl.org/coar/resource_type/c_db06uuid:0c0c8f92-e146-4e2a-b7f3-6d27a9b12387NeurosciencePhysiology and anatomyBiologyEnglishOxford University Research Archive - Valet2009Tukker, JJSomogyi, PKlausberger, T<p>The activity of networks subserving memory and learning in the hippocampus is under the control of GABAergic interneurons. In order to test the contribution of distinct cell types, I have recorded extracellularly, labelled, and identified different types of interneuron in area CA3 of the hippocampus, a region implicated in the generation of gamma and theta oscillations, and the initiation of sharp-waves.</p> <p>I present here a detailed analysis of the spike timing of parvalbumin-positive (PV) basket and physiologically identified pyramidal cells in area CA3, relative to various network states recorded in area CA3 and CA1 simultaneously. Additionally, I have shown by detailed analysis that five classes of previously recorded and identified CA1 interneuron fired with cell type specific firing patterns relative to local gamma oscillations.</p> <p>In CA3, PV basket cells fired phase locked to theta and gamma oscillations recorded in CA1 as well as in CA3, and increased their firing rates during CA1 sharp-waves. Pyramidal cells in CA3 were also phase-locked, but fired at phases different from basket cells. During theta oscillations, CA3 pyramidal and PV basket cells were phase locked to both CA1 and CA3 theta equally, suggesting a wide coherence of these oscillations; in contrast, cells fired more strongly phase-locked to gamma oscillations in CA3 than in CA1, suggesting a specific role for CA3 in the generation of this rhythm. In contrast to theta and gamma oscillations, CA3 basket cells were phase-locked to ripples in area CA3 but not in CA1.</p> <p>Overall, my results show that the spike timing of several types of interneuron in CA1, and PV basket cells in CA3, is correlated in a cell- and area-specific manner with the generation of particular states of synchronous activity.</p> |
| spellingShingle | Neuroscience Physiology and anatomy Biology Tukker, JJ Determinants of neuronal firing patterns in the hippocampus |
| title | Determinants of neuronal firing patterns in the hippocampus |
| title_full | Determinants of neuronal firing patterns in the hippocampus |
| title_fullStr | Determinants of neuronal firing patterns in the hippocampus |
| title_full_unstemmed | Determinants of neuronal firing patterns in the hippocampus |
| title_short | Determinants of neuronal firing patterns in the hippocampus |
| title_sort | determinants of neuronal firing patterns in the hippocampus |
| topic | Neuroscience Physiology and anatomy Biology |
| work_keys_str_mv | AT tukkerjj determinantsofneuronalfiringpatternsinthehippocampus |