Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid

Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid

5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (ezutromid, 1) is a first-in-class utrophin modulator that has been evaluated in a phase 2 clinical study for the treatment of Duchenne muscular dystrophy (DMD). Ezutromid was found to undergo hepatic oxidation of its 2-naphthyl substituent to pro...

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Bibliographic Details
Main Authors:	Chatzopoulou, M, Claridge, T, Davies, K, Davies, S, Elsey, D, Emer, E, Fletcher, A, Harriman, S, Robinson, N, Rowley, J, Russell, A, Tinsley, J, Weaver, R, Wilkinson, I, Willis, N, Wilson, F, Wynne, G
Format:	Journal article
Language:	English
Published:	American Chemical Society 2019

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