Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.

BACKGROUND: Sustained pressure overload induces pathological cardiac hypertrophy and dysfunction. Oxidative stress linked to nitric oxide synthase (NOS) uncoupling may play an important role. We tested whether tetrahydrobiopterin (BH4) can recouple NOS and reverse preestablished advanced hypertrophy...

Full description

Bibliographic Details
Main Authors: Moens, A, Takimoto, E, Tocchetti, C, Chakir, K, Bedja, D, Cormaci, G, Ketner, E, Majmudar, M, Gabrielson, K, Halushka, M, Mitchell, J, Biswal, S, Channon, K, Wolin, MS, Alp, N, Paolocci, N, Champion, H, Kass, D
Format: Journal article
Language:English
Published: 2008

Similar Items

Similar Items